网络游戏成瘾者前扣带回功能连接静息态fMRI研究  

Functional connectivity of anterior cingulate cortex in online game addicts： a resting-state fMRIstudy

作　　者：翁传波 钱若兵[1] 傅先明[1] 林彬[1] 季学兵[2] 牛朝诗[1] 汪业汉[1] 

机构地区：[1]安徽医科大学附属省立医院神经外科,合肥230001 [2]安徽医科大学附属省立医院影像科,合肥230001

出　　处：《中华神经医学杂志》2012年第12期1242-1246,共5页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金（30670683、30973084）;安徽省自然科学基金（070413264x、11040606M167）;安徽省卫生厅医学科研课题（0981371）

摘　　要：目的探讨青少年网络游戏成瘾者静息态下前扣带回功能连接的变化情况，从功能连接的角度解释前扣带回在网络游戏成瘾中的作用。方法选择自2011年3月至10月在安徽医科大学附属省立医院心理门诊就诊的网络成瘾者17例为成瘾组，同期招募17例健康志愿者为正常对照组。对34例被试者一般情况进行了解并比较两组之间差异；成瘾组和正常对照组分别进行静息态fMRI扫描，数据采集后进行预处理，分别以左、右前扣带回为感兴趣脑区与全脑进行功能连接分析．比较成瘾组和正常对照组前扣带回功能连接的变化情况。结果成瘾组每日或每周平均网络游戏时间及网络游戏渴求程度明显高于正常对照组，差异有统计学意义（P＜0．05）；在静息态下．正常对照组与网络成瘾组的前扣带回都与前额叶、中后扣带回、伏核、中脑、颞叶及枕叶等脑区存在功能连接关系，与全脑其他脑区比较差异（体素差异）有统计学意义（P＜0．05）；但与正常对照组比较，在静息态下成瘾组前扣带回与中脑、扣带回皮层、伏核及辅助运动区功能连接增强，与双侧前额叶、颞叶及枕叶功能连接减弱（P＜0．05）。结论网络游戏成瘾者前扣带回功能连接存在异常并可能与网络游戏成瘾的产生和维持有关。Objective To explore the changes of fimctional connectivity of anterior cingulatecortex （ACC） in online game addicts during the resting state, and to analyze the function of ACC in the pathogenesis of online game addiction from a perspective of resting-state functional connectivity. Methods Seventeen online game addicts treated in our hospital from March 2011 to October 2011 were recruited as addiction group and 17 healthy controls at the same period were recruited as HC group. The baseline characteristics of all 34 subjects were investigated and compared between the addiction group and the HC group. All fMRI data were preprocessed after a resting-state fMRI scan, and then, the left and right anterior cingulate cortexes were selected as regions of interest （ROIs） to calculate the linear correlation between the ACC and the entire brain to compare the differences between the online game addicts and normal controls. Results Obvious differences between the addiction group and HC group were noted in hours and days of online game using and degree of thirst to play online games （P〈0.05）; within the functional connectivity of ACC during the resting state, in contrast to the controls, the online game addicts showed increased connectivity with posterior cingulate, medium cingulate, midbrain, nucleus accumbens and supplementary motor area, but reduced connectivity with prefrontal cortex,temporal lobe and occipital lobe （P〈0.05）. Conclusion Altered functional connectivity of the ACC reflects the dysfunction in ACC of online game addicts, which may be linked to the forming and maintaining of the online game addiction.

关 键 词：网络游戏成瘾 前扣带回 静息态fMRI 功能连接 

分 类 号：R445.2[医药卫生—影像医学与核医学]