淀粉样前体蛋白胞内域的功能和机制  

Functions and mechanisms of intracellular domain of amyloid precursor protein

作　　者：李雯[1] 王嘉[2] 肖志成[3] 马全红[1,4] 

机构地区：[1]昆明医科大学分子临床医学研究院,昆明650500 [2]北京军区总医院京西医院,北京100144 [3]莫纳什大学免疫与于细胞实验室,墨尔本3800 [4]苏州大学神经科学研究所,苏州215123

出　　处：《中华神经医学杂志》2012年第12期1286-1290,共5页Chinese Journal of Neuromedicine

摘　　要：Alzheimer's disease (AD),a degenerative neurological disorder,is the most common form of dementia among older people,whose symptoms include gradual memory loss,cognitive impairments and deterioration of language skills.Amyloid precursor protein (APP) is cleaved by serials of secretases and generates Aβ,sAPPα/β and APP intracellular domain (AICD).Aβ forms amyloid plaques,together with neurofibrillary tangles (NFTs) which is comprised with hyperphosphorylated tau,are hallmarks ofAD.Aβ,especially in its oligomeric form,plays important roles in AD,causing cell death,calcium influx,loss of spines and repression of long-term potentiation (LTP)[1].However,recent studies indicate that in addition to Aβ,other fragments of APP after its cleavage,such as AICD,play essential roles in AD as well.In this article,the function of AICD and its underlying mechanisms will be reviewed.Alzheimer＇s disease （AD）, a degenerative neurological disorder, is the most common form of dementia among older people, whose symptoms include gradual memory loss, cognitive impairments and deterioration of language skills. Amyloid precursor protein （APP） is cleaved by serials of secretases and generates Aβ, sAPPα/βand APP intracellular domain （AICD）. Aβ forms amyloid plaques, together with neurofibrillary tangles （NFTs） which is comprised with hyperphosphorylated tau, are hallmarks ofAD. Aβ,

关 键 词：阿尔茨海默病 淀粉样前体蛋白 淀粉样前体蛋白胞内域 

分 类 号：R749.16[医药卫生—神经病学与精神病学]