子宫内膜样腺癌组织GLUT-1和VEGF表达相关性分析  

Expression of GLUT-1 and VEGF in endometrial adenocarcinoma tissues

作　　者：方志文[1] 刘欣[1] 王丽[1] 于国华[1] 

机构地区：[1]潍坊市人民医院妇科,山东潍坊261041

出　　处：《中华肿瘤防治杂志》2012年第19期1489-1491,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:通过检测葡萄糖转运蛋白-1(GLUT-1)和血管内皮生成因子(VEGF)在子宫内膜病变中的表达,探讨其与子宫内膜样腺癌发生发展的关系。方法:应用免疫组化(PV9000二步法)检测36例子宫内膜样腺癌、18例子宫内膜不典型增生、12例复杂性增生和15例单纯性增生组织中GLUT-1和VEGF的表达。结果:GLUT-1和VEGF在子宫内膜样腺癌组织中的表达分别为83.3%和75.0%,与单纯性增生、复杂性增生及不典型增生组织相比较,差异均有统计学意义,P<0.05。子宫内膜病变组织中GLUT-1与VEGF表达水平间存在正相关关系,r=0.65,P<0.01。结论:GLUT-1和VEGF在子宫内膜病变由良性到恶性转变过程中起重要作用。VEGF通过上调GLUT-1的表达,促进子宫内膜样腺癌的发生发展,具有临床应用价值。OBJECTIVE： To investigate the expression of glucose transpoter protein-1（GLUT-1） and vascular endo- thelial growth faetor（VEGF） in endometrial simple hyperplasia,complex hyperplasia,atypical hyperplasia and endometrial adenocarcinoma. METHODS： The immunohistochemical （PV9000 two-step） method was applied to detect the expression of GLUT-1 and VEGF in the endometrial simple hyperplasia（15 cases）, complex hyperplasia （12 cases）, atypical hyper- plasia （18 cases）,and endometrial adeno carcinoma （36 cases）. RESULTS： The difference of expression of GLUT-1 and VEGF in endometrial adenocarcinoma were 83.3 % and 75.0%, which were significantly different from those in endome- trial simple hyperplasia, complex hyperplasia and atypical hyperplasia tissue were statistically significant （P 〈 0. 05）. There were positive correlation anmong GLUT-1 and VEGF （r=0.65,P〈0.01）. CONCLUSIONS： GLUT-1 and VEGF can play important roles in the development of endometrial carcinoma. The expression of GLUT-1 is positively associated with VEGF. They play important roles in the carcinogenesis of endometrial carcinoma,and has certain value in clinical ap- plication.

关 键 词：子宫内膜肿瘤 单糖转运蛋白质类 血管生成因子 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]