食道癌患者血清可溶性肿瘤坏死因子受体1测定及临床意义  

Determination of the levels of serum soluble tumor necrosis factor receptor 1 in esophageal carcinoma patients

作　　者：高蕾[1] 南清振 白岚 杨希山 姜云飞[2] 

机构地区：[1]第一军医大学南方医院全军消化研究所,广东广州510515 [2]第一军医大学南方医院检验科,广东广州510515

出　　处：《第一军医大学学报》2000年第3期260-261,共2页Journal of First Military Medical University

基　　金：广东省自然科学基金资助(980120)

摘　　要：目的 探讨食管癌患者的异常免疫状态下血清sTNFR1检测的临床意义。材料和方法 用双单抗夹心酶联免疫吸附法（ELISA）检测40例食管癌患者和30例正常人血清sTNFR1水平。结果 食管癌病人血清sTNFR1浓度[（129.45±42.54）U/ml]显著高于正常人[（51.64±26.67 U/ml），P<0.05]，且其升高程度与病变食管长度、病情轻重及有无恶液质有关。结论 sTNFR1的检测对食道癌的早期诊断和预后具有实用价值。Objective To study the clinical significance of the detection of serum soluble tumor necrosis factor receptor 1(sTNFR1) in esophageal carcinoma patients. Methods Forty esophageal carcinoma patients and 30 healthy persons as control were studied. Serum sTNFR1 was measured by double monoclonal-antibody sandwich ELISA. Results Serum sTNFR1 in esophageal cancer (129.45±42.54 U/ml ) was significantly higher than that in control group (51.64±26.67 U/ml), P<0.001. The increase of sTNFR1 correlated with the range of pathologic process, state of the illness and negative or positive for cachexia. Conclusions The determination of serum levels of sTNFR1 may serve as a diagnostic aid in the early diagnose and prognosis of esophageal carcinoma.

关 键 词：可溶性肿瘤坏死因子受体1 ELISA 食管癌 

分 类 号：R735.1[医药卫生—肿瘤]