T-VAD与VAD方案治疗多发性骨髓瘤的疗效对比观察  

Comparing Observation on T-VAD and VAD Programme on the Treatment of Multiple Myeloma

作　　者：郭丽堃[1] 黎民君[1] 罗华山[1] 钟樱红[1] 冯思琼[1] 

机构地区：[1]广东省梅州市人民医院血液内科,广东梅州514031

出　　处：《河北医学》2013年第1期18-20,共3页Hebei Medicine

摘　　要：目的:比较沙利度胺联合VAD与VAD两种治疗方案对于多发性骨髓瘤患者的治疗效果及副作用。方法:将从2007年3月至2011年3月到本院就治的72例多发性骨髓瘤患者随机平分为T-VAD方案治疗组及VAD方案治疗组,比较两组患者的治疗效果及不良反应发生情况。结果:T-VAD方案治疗组中,显效的有6例,有效的有25例,总有效率为86.1%;VAD方案治疗组中,显效的有2例,有效的有19例,总有效率为58.3%。T-VAD方案治疗组中有8例发生不良反应,占22.2%;VAD方案治疗组中有11例发生不良反应,占30.6%。T-VAD方案治疗组比VAD方案治疗组治疗效果优越,不良反应发生率低,两组患者差异比较具有统计学意义((P<0.05)。结论:与VAD方案相比,T-VAD方案对于多发性骨髓瘤患者的治疗效果较优良、不良反应发生率较低,值得临床广泛推广。Objective： To compare T-VAD me and VAD program me treatment effects and side effects on multiple myeloma patients.Method： Chose 72 cases of multiple myeloma patients treated in our hospital from March 2007 to March 2011,and divided them into T-VAD program me treatment group and VAD program randomly,compared treatment effects and adverse reactions.Result： There were 6 cases of marked effective and 25 cases of effective in T-VAD treatment group,and its overall effective rate was 86.1%;There were 2 cases of marked effective and 19 cases of effective in VAD treatment group,and its overall effective rate was 58.3%.There were 8 cases of patients happened adverse reaction in T-VAD group,the ratio was 22.2%,while there were 11 cases of patients adverse reaction in VAD group,the ratio was 30.6%.T-VAD programme treatment group effect was better than VAD program treatment group,the happening rate of adverse reaction was lower,and the differences between two groups have statistics meaning（p0.05）.Conclusion：Compared with VAD program,T-VAD program has better treatment effect on multiple myeloma patients,and it has lower happening rate of adverse reaction,it is worthy of clinical promotion.

关 键 词：T-VAD方案 VAD方案 多发性骨髓瘤 疗效观察 

分 类 号：R733.3[医药卫生—肿瘤]