生物可吸收性甲壳素纤维增强聚乳酸复合材料体内体外降解性研究  

The Degradation Performance of Bioabsorbable Acylchitin Fiber Reinforced PLA Composite Materials in vitro and in vivo

作　　者：陈长春[1] 程海涛[2] 孙康[1] 吴人洁[1] 蒋尧[2] 

机构地区：[1]上海交通大学材料学院复合材料研究所,上海200030 [2]上海市第六人民医院骨科,上海200030

出　　处：《生物医学工程学杂志》2000年第2期117-121,共5页Journal of Biomedical Engineering

基　　金：上海市科学技术发展基金!98JC1405

摘　　要：对酸化改性甲壳素纤维增强聚乳酸复合材料板材进行了体外降解及动物体内植入实验。该复合材料板材初始弯曲强度为114．72MPa，初始弯曲模量为3980．05MPa。在37℃，乳酸钠林格组织液中浸泡16周后，其弯曲强度降至31．42MPa。其体外耐水解特性及耐强度衰减特性均明显优于初始弯曲强度远高于它的PGA／PLA和PGA自增强复合材料。该复合材料的降解产物可通过体内代谢吸收，提示了该材料潜在的应用前景。The present authors have investigated the degradation performance of acylchitin fiber reinforced polylactide composite materials plates both in vitro and in vivo. The initial flexural strength and the initial flexural modulus of this plate are 114. 72MPa and 3980. 05MPa,respectively. The flexural strength of this plate decreases to 31.42MPa after the plate has been submerged in injectio natrii lactatic ringeri tissue fluid for a period of 16 weeks at 37℃. Both the in vitro degradation performance and the strength retention of this plate are better than those of the self-reinforced PGA/PLA and PGA,though the initial strength of the latter two being much higher than tbat of the former. The degradation products of the chitin/PLA composite materials can be absorbed by metabolic path way.

关 键 词：酰化改性 甲壳素 聚乳酸 复合材料 体外降解 

分 类 号：R318.08[医药卫生—生物医学工程] O636.1[医药卫生—基础医学]