冷激发及钙离子通道阻滞剂对原发性开角型青光眼患者视盘血流的影响  

The influence of cold provocation and calcium channel blocker to the optic disc blood flow of patients with primary open-angle glaucoma

作　　者：邓一芸[1] 陈晓明[1] 宋广瑶[1] 

机构地区：[1]华西医科大学附属第一医院眼科,成都610041

出　　处：《中华眼底病杂志》2000年第2期85-87,共3页Chinese Journal of Ocular Fundus Diseases

基　　金：四川省卫生厅科学研究基金!资助项目 (981 0 62 )

摘　　要：目的　研究原发性开角型青光眼 (primary open- angle glaucoma,POAG)患者在寒冷刺激及服用钙离子通道阻滞剂后视盘血流的变化。　 方法　 用海德堡视网膜血流仪 (Heidelberg retinal flowmetry,HRF)分别测量 POAG患者与正常个体视盘筛板区微血管在基础状态下、手指冷激发试验后及含服硝苯吡啶后的血流情况。　结果　 POAG患者在冷激发试验后视盘平均血管容积及平均血流量分别由 2 7.1与5 45 .4降至 2 2 .3与 45 2 .4(P<0 .0 5 ) ,在含服硝苯吡啶后平均血管容积及平均血流量分别升至 2 9.0与5 79.5 (P<0 .0 5 )。有手足发冷史的 POAG患者在冷激发条件下视盘血流平均下降值为 137.2 ,在含服硝苯吡啶后视盘血流平均增加值为 196 .4,与无手足发冷史的 POAG患者比较差异均有显著性意义 (P<0 .0 5 )。　结论　POAG患者视盘血流受冷刺激后明显下降。钙离子通道阻滞剂可提高部分 POAG患者即时视盘血流。手足发冷史与 POAG患者的血流变化有密切关系。Purpose [WT5”BZ]To examine the change of optic disc blood flow in primary open angle glaucoma (POAG) patients after cold provocation test and nifedipine administration. [WT5”HZ] Methods[WT5”BZ] Using Heidelberg retinal flowmetry (HRF), the blood flow of optic disc of glaucoma patients and normal control subjects were measured under basal condition, after cold provocation test,and after nifedipine administration. [WT5”HZ]Results [WT5”BZ] The mean optic disc blood volume and flow of POAG patients reduced from 27.1 and 545.4 to 22.3 and 452.4 after cold provocation test (P<0.05),and increased to 29.0 and 579.5 after nifedipine adminstration (P<0.05). The changes of mean optic disc blood flow of patients with a history of cold extremities show statistic significance compared with whom without such history (P<0.05)). [WT5”HZ] Conclusion The changes of blood flow of optic disc in POAG patients may be influenced by cold stimuli and administration of nifedipine,and the history of cold extremities might be connected with the change of optic disc blood flow in POAG patients. [WT5”HZ]

关 键 词：开角型青光眼 钙通道阻滞剂 血流速度 冷激发 

分 类 号：R775[医药卫生—眼科]