人视网膜前膜中粘附分子的免疫组织化学观察  

An immunohistochemical study of adhesion molecules in human epiretinal membranes

作　　者：张蓉[1] 惠延年[1] 马吉献[1] 

机构地区：[1]第四军医大学西京医院眼科,710032

出　　处：《中华眼底病杂志》2000年第2期106-108,共3页Chinese Journal of Ocular Fundus Diseases

基　　金：国家自然科学基金!资助项目 (39470 742 )

摘　　要：目的　观察增生性玻璃体视网膜病变 (proliferative vitreoretinopathy,PVR)的视网膜前膜(epiretinal membranes,ERM)中粘附分子 (ICAM- 1,Mac- 1)的表达。　方法　用免疫组织化学方法对 2 0例复杂视网膜脱离行玻璃体切割术时剥离的视网膜前膜进行观察。　结果　 ICAM- 1和 Mac- 1分别在 18和15例视网膜前膜中表达 ,两种粘附分子同在 12例视网膜前膜中表达。　结论　 ERM中有 ICAM- 1和Mac- 1的表达 ,提示粘附分子在 PVR的发生发展中有一定作用。Purpose To investigate the expression of intercellular adhesion molecules ICAM 1 and Mac 1,in epiretinal membanes (ERM) of eyes with proliferative vitreoretinopathy (PVR). Methods Twenty epiretinal membranes were obtained from eyes undergone vitrectomy for retinal detachment complicated with PVR and observed by immunohistochemical examination. Results Expressions of ICMA 1 and Mac 1 were observed in 18 and 15 membranes respectively.Expression of both adhesion molecules in 12 membranes. Conclusion The findings indicate that adhesion molecules might be involved in the development of PVR.

关 键 词：视网膜病变 视网膜前膜 细胞粘附分子 

分 类 号：R774.1[医药卫生—眼科]