抗细胞凋亡基因BcL-2和Bax与卵巢肿瘤的关系  

Correlation between anti-apoptosis gene BcL-2,Bax and ovarian neoplasm

作　　者：李佩玲[1] 王雪卿[1] 王姣玲[1] 付红[1] 

机构地区：[1]哈尔滨医科大学附属第二医院妇产科,黑龙江哈尔滨150086

出　　处：《哈尔滨医科大学学报》2000年第3期174-176,共3页Journal of Harbin Medical University

摘　　要：目的研究抗凋亡基因ＢｃＬ－２和凋亡基因Ｂａｘ与卵巢肿瘤发生及预后的关系。方法通过免疫组化方法，用抗ＢｃＬ－２和Ｂａｘ的抗体检测７２份卵巢肿瘤标本ＢｃＬ－２和Ｂａｘ的表达产物，并以正常卵巢１２份做对照。结果正常卵巢组织中ＢｃＬ－２和Ｂａｘ的阳性检出率为零。在良性及恶性肿瘤组织中ＢｃＬ－２的阳性检出率分别为１８／３０、６／４２，良恶性之间差异有显著性；Ｂａｘ的阳性检出率分别为５／３０、２２／４２，良恶性之间差异有显著性（Ｐ＜０．０５）。ＢｃＬ－２在恶性肿瘤ＷＨＯ分级Ⅰ－－Ⅲ级间差异无显著性，Ｂａｘ在病理分级ＷＨＯⅠ－Ⅲ级间差异有显著性。结论　抗凋亡基因ＢｃＬ－２和凋亡基因Ｂａｘ的过度表达可能与卵巢肿瘤的发生有关，但是其细胞凋亡的机制及调控方式与非肿瘤组织和其它部位的肿瘤有所不同。推测Ｂａｘ不仅参与细胞凋亡的调控，而且可能与肿瘤分化及预后有关。Objective To study the expression of anti-apoptosisgene BcL-2, apoptosis gene Bax in ovarian neoplasms and its relationship with ovarian neoplastigenesis and prognosis. Methods The expression of BcL 2, Bax in 72 ovarian neoplasms tissue, and 12 normal ovarian tissue was determined by immunohistochemistry. Results In normal tissue the positive expression of BcL-2, Bax was 0.In benign and malignant tissue, the pos itive expression of BcL-2 and Bax was 60%, 14.3%, 16.7%, 52.4%, respectively. The different expression of BcL-2, Bax between benign and malignant neoplasms was significant. The different expression of BcL-2 in ma lignant neoplasm WHO stage Ⅰ～Ⅲ was not significant. Conclusion The regulation of BcL-2 . Bax differs between normal and neoplastic ovarian tissue, the over expression of BcL-2, Bax is closely related to ovarian neplastigenesis. Moreover, the modulation of these gene in ovarian carcinoma is different compared to other tissue. Therefore tissue specificity is very important.

关 键 词：细胞凋亡 基因 BCL-2 BAX 卵巢肿瘤 

分 类 号：R737.310.2[医药卫生—肿瘤]