精神分裂症症状与血清同型半胱氨酸的相关性分析  

Symptoms of schizophrenia is relative to the Level of Serum Homocysteine

作　　者：刘洪光[1] 叶昌斌[1] 王元彬[1] 

机构地区：[1]广东省深圳市康宁医院检验科,广东深圳518020

出　　处：《现代预防医学》2012年第24期6458-6460,共3页Modern Preventive Medicine

基　　金：深圳市科技局资助项目(200903129)

摘　　要：目的探讨精神分裂症症状与血清同型半胱氨酸(Hcy)含量的相关性。方法共纳入60例精神分裂症患者,同时从门诊随机抽取60例无哮喘病史的人群作为对照组。采用阳性和阴性症状量表(PANSS)进行症状评价,并抽取空腹血检测Hcy水平。结果病例组患者治疗前比对照组血清Hcy水平明显增高,差异有统计学意义(P﹤0.05);患者治疗前和治疗后的Hcy水平、PANSS总分及各因子分均有显著下降,差异有统计学意义(P﹤0.01)。治疗前和治疗后Hcy水平与PANSS总分及N分呈正相关,Hcy变化值与PANSS总分变化值呈正相关,差异有统计学意义(P﹤0.05);男性患者Hcy水平在治疗前后均显著高于女性患者(P﹤0.05),但患者组治疗前后的Hcy变化值不存在差异。以患者平均年龄为界,年龄大小亚组之间Hcy治疗前和治疗后差异均无统计学意义(P﹥0.05)。不同药物之间比较患者Hcy水平变化量差异无统计学意义(F=0.55,P=0.74)。结论精神分裂症患者血清Hcy水平明显增高,并与性别有关,给予相应的抗精神药物治疗可以降低血清Hcy水平,但不同药物的作用差异不明显,治疗前和治疗后Hcy水平与PANSS总分及N分呈正相关,Hcy变化值与PANSS总分变化值呈正相关,因此血清Hcy可能参与了精神分裂症的发病机制。OBJECTIVE To study the serum homocysteine （Hcy） level of first-episode schizophrenia, explore the correlation between serum HCY level and episode schizophrenia. METHODS Participants included 60 patients with schizophrenia, and from 60 cases of no random outpatient service history of asthma crowd as control group. With the positive and negative symptoms scale （PANSS） symptoms evaluation, and draw blood tests on an empty stomach Hey level. RESULTS Cases before treatment group patients than the control group was higher Hcy serum level, and there was statistically significant difference between the two groups （P 〈 0.05） ; Hcy level before and after treatment, and total PANSS and other factor points were significantly de- creased, there was significantly difference （P 〈 0.01 ）. Before and after treatment, Hcy level, total PANSS scores were signifi- cantly positively associated with N scores, Hcy change value was significantly positive correlation with total value change of PANSS （P 〈 0.05） ;Hcy level of male patients before and after treatment were significantly higher than that of female patients （P 〈 0.05）, but there was no significant changes for Hcy value before and after treatment （P 〉 0.05 ）. Taking age as a cut point, there was not significant difference in Hcy value before and after treatment by age stratification （P 〉 0.05）. There was no signifi- cant different in the Hcy value between patients with different drugs （F = 0.55, P = 0.74）. CONCLUSION Patients with schizophrenia had significantly higher serum Hcy level, which was associated with gender. Antidepressant drug therapy can re- duce serum Hcy level, but there were no significant difference betweent different drugs. The Hcy level was positively related to total PANSS scores and N scores. Hcy changes were positively related to total PANSS score, so the serum Hcy may be involved in the pathogenesis of schizophrenia.

关 键 词：精神分裂症 症状 血清同型半胱氨酸 相关 

分 类 号：R749.3[医药卫生—神经病学与精神病学]