艾司西酞普兰与氟西汀治疗老年抑郁症的临床研究  

Clinical study of escitalopram and fluoxetine treated with geriatric depression

作　　者：韩天明[1] 肖玉瑛 洪亮[1] 

机构地区：[1]海南省安宁医院三科,海南海口571100

出　　处：《现代预防医学》2012年第24期6529-6530,6535,共3页Modern Preventive Medicine

摘　　要：目的探讨艾司西酞普兰治疗老年抑郁症的疗效和安全性。方法将100例年满60岁以上的抑郁患者随机分为两组,每组50例,分别使用艾司西酞普兰和氟西汀治疗,采用汉密尔顿抑郁量表(HAMD)进行疗效评定,使用药物副反应量表(TESS)评定不良反应。治疗期间监测血糖、血脂、血常规、心电图和肝肾功能。疗程6周。结果艾司西酞普兰组痊愈率46%,显效率76%,氟西汀组痊愈率40%,显效率72%,两组比较差异无统计学意义(P﹥0.05)。治疗后两组HAMD总分均较治疗前有显著下降,两组治疗前后比较差异有统计学意义(P﹤0.05),而且1周末HAMD评分与治疗前比较两组间差异有统计学意义(P﹤0.05)。艾司西酞普兰组治疗前后血糖比较差异无统计学意义(P﹥0.05),艾司西酞普兰组和氟西汀组治疗前后血糖变化比较差异有统计学意义(P﹤0.05)。艾司西酞普兰组治疗前后血脂比较差异无统计学意义(P﹥0.05),艾司西酞普兰组和氟西汀组治疗前后血脂变化比较差异有统计学意义(P﹤0.05)。艾司西酞普兰组不良反应率16%,氟西汀组不良反应率28%,两组间比较差异有统计学意义(P﹤0.05)。结论艾司西酞普兰治疗老年抑郁症患者显效快,对血糖、血脂的影响小,不良反应少,易耐受,更适合老年抑郁症患者。OBJECTIVE To investigate the efficacy and safety of escitalopram in treatment of depression. METHODS 100 de- pression patients over 60 years old were randomly divided into two groups, and 50 cases were in each group. The treatment effi- cacy of escitalopram and fluoxetine was evaluated by Hamilton Depression Scale （HAMD） adverse drug reaction scale （TESS） assessment of adverse reactions. During treatment, we monitored the blood glucose, blood lipids, blood, electrocardiogram, and liver and kidney function. Treatment duration was lasted for 6 weeks. RESULTS The cure rate of escitalopram group was 46%, and markedly effective rate was 76%. The cure rate of the fluoxetine group was 40%, and markedly effective rate was 72%. There was not significant （P 〉 0.05）. Two HAMD total score compared with treatment after treatment decreased signifi- cantly before and after treatment, and there was significant difference （P 〈 0.05）, and a weekend HAMD scores before treat- ment between two groups were compared, and there was a significant difference （P 〈 0.05）. Escitalopram before and after treat- ment blood glucose showed significant difference （P 〉 0.05）. Blood sugar changes in the escitalopram group and fluoxetine group showed significant difference before and after treatment （P 〈 0.05）. Escitalopram group of lipids before and after treatment the difference did not show not significant （P 〉 0.05）. Blood lipid changes in the escitalopram group and fluoxetine group before and after treatment the showed significant difference （P 〈 0.05）. Escitalopram adverse reaction rate was 16%. The adverse reaction rate of the fluoxetine group was 28%, and there was significant difference between the two groups （P 〈 0.05）. CONCLUSION Escitalopram treating patients with depression had markedly influence on glucose, lipids and small, and there was fewer ad- verse reaction, easily tolerated, which is more suitable for elderly patients with depression.

关 键 词：艾司西酞普兰 氟西汀 老年抑郁症 

分 类 号：R749.41[医药卫生—神经病学与精神病学]