65岁以上老年女性乳腺癌的治疗和预后  

Treatment and Prognosis of Breast Cancer in Women Aged 65 Years and Older

作　　者：蔡建强[1] 邵永孚[1] 高纪东[1] 胡敬群[1] 

机构地区：[1]中国医学科学院,肿瘤医院腹部肿瘤外科,100021

出　　处：《实用癌症杂志》2000年第2期179-181,共3页The Practical Journal of Cancer

摘　　要：目的　探讨老年女性乳腺癌的最佳治疗方法及影响预后的因素。方法　回顾性分析了 1985年 10月至 1995年 10月收治的老年女性乳腺癌的临床资料。结果　在 12 7例患者中 ,114例手术治疗 ,其中 95例在全麻或硬膜外麻醉下进行了乳腺癌根治、改良根治及单纯切除术 ,19例行肿瘤局部切除术。 9例单纯放疗 ,4例单纯化疗。 12例于术后 (局部切除 9例 ,单纯切除 3例 ) 6个月至 5年时局部复发 ,3 6例在随访 4个月至 6年时出现肺、肝、骨及脑部转移 ,3 5例在随访 8个月至 5年 7个月时死于本病 ,9例死于其它疾病。经Kaplan Meier生存率计算 ,其总的 3、5、10年生存率分别为 93 .7%、5 9.3 %及 5 8.1%。 结论　老年女性乳腺癌的临床治疗应以外科手术为主 ,并应多选择改良根治的手术方式。淋巴结转移、病理类型及肿瘤大小是影响预后的显著因素 (P <0 .0 5 )。Objective To study the optimal treatment and prognosis of breast cancer in elderly ≥65 years women.Methods A retrospective review of the database of 127 patients who were treated from Oct.1985 to Oct.1995.Results Curative resection was performed in 114 of the 127 patients,including 19 local excision and 95 radical mastectomy or modified radical mastectomy or simple mastectomy under general anesthesia or extradural spinal cord anesthesia.Nine patients received radiotherapy alone and 4 chemotherapy alone.Twelve patients(9 local excision and 3 simple mastectomy) relapsed in period of 6 months to 5 years postoperatively;36 patients developed metastases to lung,liver,or brain during follow up of 4 months to 6 years.Thirty five patients died postoperatively in 8 months to 5 years 7 months.Studied with Kaplan Meier method,the overall 3,5 and 10 year survival rate was 93.7% ,59.3% and 58.1%,respectively.Conclusion Treatment of breast cancer in elderly women should aim at operation and choice modified radical mastectomy.Lymph node status,histological type,coexisting diseases and size of tumor are the significant factors affecting prognosis( P <0.05).

关 键 词：乳腺癌 治疗 预后 老年人 

分 类 号：R737.9[医药卫生—肿瘤]