探讨热疗联合同步放化疗治疗中晚期食管癌的临床疗效  

Clinical Efficacy of Hyperthermia with Concurrent Chemoradiotherapy on Advanced Esophageal Cancer

作　　者：段宏燕[1] 祝沈冬[1] 于清蕊[1] 

机构地区：[1]辽宁省肿瘤医院放疗科,沈阳市110042

出　　处：《中华全科医学》2012年第12期1831-1832,共2页Chinese Journal of General Practice

基　　金：辽宁省自然科学基金项目(992250)

摘　　要：目的观察热疗联合同步放化疗治疗中晚期食管癌的近期疗效、毒副反应。方法 132例不能手术或不同意手术的中晚期食管癌患者,随机分成两组,每组66例,治疗组应用深部热疗联合同步放化疗,对照组应用同步放化疗,比较两组近期疗效和不良反应。结果近期疗效全部病例均完成治疗,无退组病例。治疗组和对照组总疗效分别为90.9%和69.7%,治疗组近期疗效高于对照组,差异有统计学意义(P<0.05);治疗组在骨髓抑制、胃肠道反应及放射性食管炎发生率方面均低于对照组,差异有统计学意义(P<0.05)。结论热疗联合同步放化疗治疗中晚期食管癌疗效优于同步放化疗,并且降低了放化疗的不良反应,值得进一步探讨。Objective To observe the short-term efficacy and toxic reaction and side effect of hyperthermia combined with concurrent chemoradiotherapy on advanced esophageal cancer. Methods Total 132 patients with advanced esophageal cancer ei- ther were inoperable or refused operation were randomized into two groups, each group was 66 cases. The treatment group received hyperthermia combined with concurrent chemoradiotherapy ;while the control group was treated only with concurrent chemoradio- therapy. The short-term efficacy and side effects were evaluated. Results All the treatment for 132 cases were completed,there was no patients of retreat. The total effect of the treatment group and control group were 90.9% and 69.7% ,respectively,the o- verall response rate of treatment group was higher than that of the control group, the differences were statistically significant （P 〈 0.05 ）. The incidence rate of bone marrow suppression, gastrointestinal reactions and radioactive esophagitis in treatment group was lower than that in the control group, the differences were statistically significant （P 〈 0.05 ）. Conclusion The clinical effects of hyperthermia combined with concurrent chemoradiotherapy for advanced esophageal cancer was better than that of radiotherapy and chemotherapy combination,and hyperthermia can also reduce adverse reactions of chemoradiotherapy, it was well further to study.

关 键 词：食管癌 热疗 放射治疗 化学治疗 

分 类 号：R735.1[医药卫生—肿瘤] R730.53[医药卫生—临床医学]