协同刺激分子B7-H3在结直肠癌中表达的临床意义  

Clinical significance of co-stimulatory molecule B7-H3 expression in colorectal cancer

作　　者：茆勇[1] 孙静[2] 汪维鹏[2] 华东[1] 

机构地区：[1]苏州大学附属第四医院肿瘤科,无锡214062 [2]苏州大学医学部,苏州215007

出　　处：《癌症进展》2012年第6期538-541,共4页Oncology Progress

基　　金：国家自然科学基金(81201600);江苏省自然科学基金(BK2012538);无锡市医院管理中心项目(YGM1018)

摘　　要：目的探讨协同刺激分子B7-H3在结直肠癌中的表达与患者临床病理参数的相关性。方法收集2003年1月至2003年12月在苏州大学附属第四医院行手术切除术的结直肠癌患者组织标本98例,采用免疫组织化学方法检测结直肠癌组织中协同刺激分子B7-H3的表达,分析B7-H3分子在结直肠癌组织中的表达水平。结果 B7-H3分子在结直肠癌癌灶及间质中均高表达,与患者的年龄、性别、肿瘤分期、分化程度无相关性(P>0.05),但间质高表达B7-H3分子与患者淋巴结转移显著相关(P<0.05)。结论协同刺激分子B7-H3在结直肠癌间质中高表达与患者淋巴结转移相关,对结直肠癌患者的预后判断具有潜在的临床应用价值。Objective To investigate the correlation between the negative costimulatory molecule B7-H3 expression and clinieopathologieal parameters in eoloreetal correlation. Methods 98 patients of coloreetal cancer in the Forth Affilia- ted Hospital of Sooehow University from January 2003 to December 2003, immunohistochemistry was used to detect colorec- tal cancer tissues costimulatory molecules B7-H3 expression, analysis of the expression levels of B7-H3 molecules in color- eetal cancer tissues and correlation with elinicopathological parameters. Results B7-H3 molecule highly expressed in coloreetal cancer foci and interstitial, and there was no correlation with the patient＇s age, gender, tumor stage, differentia- tion degree （ P 〉 0. 05 ）, but high expression of B7-H3 molecular in interstitial has significant correlation with lymph node metastasis in patients （P 〈 0.05）. Conclusion Negative costimulatory molecules B7-H3 is highly expressed in eolorec- tal cancer foci and interstitial. High expression of B7-H3 molecular in interstitial has significant correlation with lymph node metastasis in patients, and has potential clinical value of prognosis in eoloreetal cancer patients.

关 键 词：结直肠癌 协同刺激分子 B7-H3 预后 

分 类 号：R735.35[医药卫生—肿瘤] R735.37[医药卫生—临床医学]