系统性硬化症患者高分辨率测压下食管动力特点  

Esophageal motor function of systemic sclerosis with high resolution manometry

作　　者：张秀静[1] 向雪莲[1] 涂蕾[1] 沈凌汛[2] 崔舜[2] 陶娟[3] 谢小平[1] 侯晓华[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院消化内科,武汉430022 [2]华中科技大学同济医学院附属协和医院风湿科,武汉430022 [3]华中科技大学同济医学院附属协和医院皮肤科,武汉430022

出　　处：《临床内科杂志》2012年第11期776-778,共3页Journal of Clinical Internal Medicine

摘　　要：目的应用高分辨率测压的方法对系统性硬化症患者食管运动功能及其与食管症状的关系进行研究。方法选择临床确诊为系统性硬化症的患者18例，均接受36通道高分辨率食管测压检查，记录食管括约肌静息压力、10次5ml水及10ml水连续吞咽状态下食管体部蠕动情况。结果18例受试者中失蠕动8例，弱蠕动9例（频发性无蠕动及大缺损性弱蠕动7例），下食管括约肌压力降低8例。连续吞咽中88．9％的患者未见蠕动波出现。10例存在食管症状者中，失蠕动患者6例，食管体部弱蠕动4例。无食管症状者中，2例失蠕动，5例食管体部弱蠕动。结论食管功能异常在系统性硬化症患者中发生率较高，疾病早期无食管症状者即可出现食管动力异常。Objective To evaluate esophageal motor of patients with systemic sclerosis by high resolution manometry （HRM） and explore the relationship between esophageal motility and symptoms. Methods Eighteen patients with systemic sclerosis （2 males and 16 females） underwent 36 channel solid- state high resolution manometry. Basal pressure esophageal sphincter were recorded, continuous swallowing of 5 ml and 10 ml water were given for testing the esophageal body motility according to the Chicago clas- sification. Results Of 18 patients,8 had aperistalsis and 9 had weak peristalsis（7 cases had frequent peristalsis failure or weak peristalsis with large defects）. Hypotensive lower esophageal sphincter （LES） was present in 8 patients. Sequential swallowing in 88.9% patients didn＇t show peristaltic waves. Of 10 subjects with esophageal symptoms,6 had aperistalsis and 4 had weak peristalsis. Of those patients without esophageal symptoms,2 had aperistalsis and 5 had weak peristalsis of esophageal body. Conclusion Dys- function of esophagus occurs frequently in systemic sclerosis, esophageal dysmotility could be seen before esophageal symptoms in the early stage of this disease.

关 键 词：系统性硬化症 高分辨率测压 食管动力 

分 类 号：R571[医药卫生—消化系统] R593.25[医药卫生—内科学]