Highly Enantioselective Michael Addition of Ketone to Alkylidene Malonates Catalyzed by Binaphthyl Sulfonimides in Water  

作　　者：贾胜见 罗春华 杜大明 

机构地区：[1]School of Chemical Engineering and Environment,Beijing Institute of Technology,Beijing 100081,China

出　　处：《Chinese Journal of Chemistry》2012年第11期2676-2680,共5页中国化学（英文版）

基　　金：Acknowledgment We are grateful for financial support from the National Natural Science Foundation of China （No. 21072020）, the Science and Technology Innovation Program of Beijing Institute of Technology （No. 2011CX01008） and the Development Program for Distinguished Young and Middle-aged Teachers of Beijing Institute of Technology.

摘　　要：Binaphthyl sulfonimides have been developed to catalyze the asymmetric Michael addition of ketone to alky- lidene malonates, affording the corresponding Michael products in good to high yields （up to 98%） with good to excellent diastereoselectivity （up to 99 ; 1 dr） and enantioselectivity （up to 92% ee） under mild conditions using environmentally benign water as the solvent.Binaphthyl sulfonimides have been developed to catalyze the asymmetric Michael addition of ketone to alky- lidene malonates, affording the corresponding Michael products in good to high yields （up to 98%） with good to excellent diastereoselectivity （up to 99 ; 1 dr） and enantioselectivity （up to 92% ee） under mild conditions using environmentally benign water as the solvent.

关 键 词：asymmetric catalysis ORGANOCATALYSIS Michael addition MALONATES sulfonimides 

分 类 号：O623.413[理学—有机化学] O621.256.7[理学—化学]