糖皮质激素治疗急性肝损伤期间的血糖升高  

Elevation of blood glucose during the treatment of acute liver injury with glucocorticoid

作　　者：杨柳[1] 甘建和[1] 冯婷婷[1] 黄小平[1] 陈科 王晓红 

机构地区：[1]苏州大学附属第一医院感染病科,江苏省215006 [2]盐城市第二人民医院感染病科

出　　处：《江苏医药》2012年第23期2801-2803,共3页Jiangsu Medical Journal

基　　金：国家"十二五"科技重大专项资助(2010ZX10002004-008)

摘　　要：目的观察糖皮质激素冲击治疗急性肝损伤时血糖升高的作用。方法 20例急性肝损伤患者,11例给予糖皮质激素冲击治疗(治疗组),9例未给予激素治疗(对照组)。定期监测肝功能、空腹及三餐后2-h血糖。结果 20例患者均好转出院。与治疗前空腹血糖水平(4.71±0.96)mmol/L相比,治疗组三餐后血糖均明显升高[(11.34±2.84)mmol/L、(15.42±4.69)mmol/L、(19.73±4.70)mmol/L](P<0.05);而对照组治疗前后三餐后血糖无明显差异;两组治疗前后空腹血糖均无明显变化(P>0.05)。治疗组住院(12.38±8.03)d,与对照组的(15.56±4.77)d相仿(P>0.05)。结论糖皮质激素冲击治疗急性肝损伤的效果是肯定的;但治疗期间可引起血糖升高,可能与肝脏受损程度及年龄有一定关系。Objective To observe the elevation of blood glucose（BG） during the treatment of acute liver injury with glucocorticoid.Methods Twenty patients with acute liver injury were treated with glucocorticoid（group A,11 cases） or without（group B,9 cases）.The liver functions,fasting BG and BG levels after meal were monitored.Results Twenty patients were discharged with improved liver functions.Compared to before [（4.71±0.96） mmol/L],BG levels after meals were higher during treatment in group A [（11.34±2.84） mmol/L,（15.42±4.69） mmol/L and（19.73±4.70） mmol/L]（P0.05）,which were not significantly changed in group B.The fasting BG was not significantly different before and during treatment in both groups（P0.05）.The hospital stay of group A was similar to that of group B [（12.38±8.03） d vs.（15.56±4.77） d]（P0.05）.Conclusion The efficacy of glucocorticoid treatment on acute liver injury is definite.Druing glucocorticoid treatment in the patients with acute liver injury,the elevation of BG is remarkable,which may be related to the severity of liver injury and age of the patients.

关 键 词：糖皮质激素 血糖 急性肝损伤 

分 类 号：R575[医药卫生—消化系统]