结肠癌肝转移术后经脐静脉置管门静脉灌注化疗的效果  

Outcomes of chemotherapy via portal vein through umbilical vein catheter in colon cancer patients with liver metastases after surgery

作　　者：王炜[1,2] 黄世锋[1,2] 陈德伦[1,2] 徐君毅[1,2] 谢德智[1,2] 

机构地区：[1]广西医科大学第四附属医院 [2]柳州市工人医院普通外科,广西省545005

出　　处：《江苏医药》2012年第23期2837-2839,共3页Jiangsu Medical Journal

基　　金：广西省卫生厅2010年度自筹科研项目(Z2010429)

摘　　要：目的探讨经脐静脉置管门静脉灌注化疗防治结肠癌肝转移的效果。方法结肠癌肝转移的患者61例随机分为两组,均先行结肠癌原发病灶和肝转移癌肿切除术。治疗组31例,术中经脐静脉至门静脉置管放置化疗泵,术后灌注化疗;对照组30例,术后经静脉行全身化疗。结果随访至1年时,治疗组再次出现肝内转移率13.7%,明显低于对照组的41.1%(P<0.05)。治疗组1年生存率为72.4%,明显高于对照组的41.3%(P<0.05)。治疗组肝功能损伤的发生率明显高于对照组(45.2%vs.20.0%)(P<0.05)。两组胃肠道不良反应、骨髓抑制及末梢神经毒性的发生率相仿(P>0.05)。结论经脐静脉置管门静脉灌注化疗能有效降低结肠癌肝转移术后肝内复发率,延长患者生存期。Objective To study the clinical efficacy of chemotherapy via portal vein in colon cancer patients with liver metastases after surgery.Methods A total of 61 cases of colon cancer with liver metastasis underwent the resections of primary colon lesion and liver metastasis lesion,who were randomly divided into two groups of A（31 cases,postoperative chemotherapy via portal vein through umbilical vein catheter） and B（30 cases,postoperative systemic venous chemotherapy）.Results The patients were followed up for one year.The recurrence rate of intrahepatic metastasis was lower in group A than that in group B（13.7% vs.41.1%）（P0.05）.The one-year survival rate was higher in group A than that in group B（72.4% vs.41.3%）（P0.05）.The incidence rate of liver damage was higher in group A than that in group B（45.2% vs.20.0%）（P0.05）.There were no significant differences in the incidence of gastrointestinal side effects,bone marrow suppression and peripheral neurotoxicity between two groups（P0.05）.Conclusion Chemotherapy via portal vein through umbilical vein catheter in colon cancer patients with liver metastases after surgery may effectively reduce the recurrence rate of intrahepatic metastasis and prolong the survival period.

关 键 词：结肠癌 门静脉化疗 

分 类 号：R735[医药卫生—肿瘤]