脑梗死患者血浆同型半胱氨酸和纤维蛋白原水平与颈动脉粥样硬化斑块稳定性的关系  

Relationship of plasma homocysteine and fibrinogen and the stability of carotid atherosclerotic plaque in patients with cerebral infarction

作　　者：吴银艳[1] 吴臣义[2] 陈卓友[1] 

机构地区：[1]南京医科大学附属常州第二医院神经内科,江苏省213162 [2]南京医科大学附属常州第二医院神经外科,江苏省213162

出　　处：《江苏医药》2012年第23期2853-2854,共2页Jiangsu Medical Journal

摘　　要：目的探讨脑梗死患者血浆同型半胱氨酸(Hcy)和纤维蛋白原(Fg)水平与颈动脉粥样硬化斑块稳定性的关系。方法根据颈动脉彩色超声多普勒检查结果将70例脑梗死患者分为无斑块组(14例)、不稳定斑块组(34例)和稳定斑块组(22例),测定Hcy和Fg水平。结果不稳定斑块组Hcy和Fg为(21.76±9.82)μmol/L、(3.78±0.58)g/L,均显著高于无斑块组的(14.09±3.05)μmol/L、(3.12±0.36)g/L和稳定斑块组的(16.79±3.56)μmol/L、(3.52±0.42)g/L(P<0.05,P<0.01)。随着Hcy和Fg水平的升高,颈动脉不稳定斑块的发生率升高。结论颈动脉斑块的发生及其稳定性与Hcy和Fg水平关系密切。Objective To investigate the relationship between plasma levels of homocysteine（Hcy） and fibrinogen（Fg） and the stability of carotid atherosclerotic plaque in patients with cerebral infarction.Methods On the basis of carotid ultrasonography,70 patients with cerebral infarction were divided into three groups of A（14 cases without plaque）,B（34 cases with unstable plaque） and C（22 cases with stable plaque）.Plasma Hcy and Fg were measured.Results Plasma Hcy and Fg in group B were（21.76±9.82） μmol/L and（3.78±0.58） g/L,respectively,which were higher than（16.79±3.56） μmol/L and（3.52±0.42） g/L in group C and（14.09±3.05） μmol/L and（3.12±0.36） g/L in group A（P0.05 or P0.01）.The incidence rate of carotid atherosclerotic unstable plague increased as plasma levels of Hcy and Fg increased.Conclusion The formation and stability of carotid therosclerotic plaque are closely related to plasma levels of HCY and Fg.

关 键 词：脑梗死 动脉粥样硬化斑块 同型半胱氨酸 纤维蛋白原 

分 类 号：R743[医药卫生—神经病学与精神病学]