三阴性乳腺癌临床病理特征和预后分析  

Analysis of clinicopathological characteristics and prognosis of triple negative breast cancer

作　　者：杨荣华[1] 虞敏晶[1] 徐玲玉[1] 张桂普[1] 

机构地区：[1]苏州大学附属常州肿瘤医院乳腺外科,江苏省213001

出　　处：《江苏医药》2012年第23期2857-2859,共3页Jiangsu Medical Journal

摘　　要：目的分析雌激素受体(ER)、孕激素受体(PR)和人类表皮生长因子受体2(HER-2)三阴性乳腺癌的临床病理特征和预后。方法经病理确诊的乳腺癌患者613例分为三阴性乳腺癌组(A组,122例)和非三阴性乳腺癌组(B组,491例)。比较两组患者的临床病理特征、复发和远处转移及生存情况。结果 A组髓样癌发生率21.3%,组织学Ⅲ级占60.6%,p53基因阳性表达率73.7%,均明显高于B组的5.9%,30.9%,40.9%(P<0.05);A组淋巴结转移率高于B组(49.2%vs.40.1%)P<0.05);A组局部复发率和肝、肺转移率均显著高于B组(P<0.05)。生存分析显示,A组5年无瘤生存率和5年总生存率分别为65%和81%,均显著低于B组的76%和88%(P<0.05)。结论三阴性乳腺癌具有特定的临床特征,无瘤生存率和总生存率明显低于非三阴性乳腺癌患者。Objective To analyze the clinicopathological characteristics and prognosis of estrin receptor（ER）,progestin receptor（PR） and human epidermal groth factor recepter 2（HER-2） triple negative breast cancer（TNBC）.Methods A total of 613 patients with breast cancer confirmed by pathology were divided into two groups of A（122 cases with TNBC） and B（491 cases,with non-TNBC）.The clinicopathological characteristics,recurrence and survival of the patients were analyzed.Results The incidence rates of medullary cancer and grade Ⅲ were higher in group A than those in group B（21.3% vs.5.9% and 60.6% vs.30.9%）（P0.05）.The expression rate of p53 was higher in group A than that in group B（73.7% vs.40.9%）（P0.05）.The local lymph node metastasis rate was higher in group A than that in group B（49.2% vs.40.1%）（P0.05）.The local occurrence rate and lung and liver metastasis rates were significantly higher in group A than those in group B（P0.05）.The 5-year disease-free and overall survival rate were significantly lower in group A than those in group B（65% vs.76% and 81% vs.88%）（P0.05）.Conclusion TNBC has some specific clinicopathological characteristics.The disease-free and overall survival rates of TNBC patients are significantly lower than those of non-TNBC ones.

关 键 词：乳腺癌 

分 类 号：R737[医药卫生—肿瘤]