垂体后叶素联合肾上腺素在心肺复苏中的应用  

Application of pituitrin combined with adrenaline on cardiopulmonary resuscitation

作　　者：蒋勇[1] 李华丽[1] 

机构地区：[1]广东省英德市人民医院ICU,广东英德513000

出　　处：《中国医药科学》2012年第18期28-30,共3页China Medicine And Pharmacy

摘　　要：目的探讨垂体后叶素联合肾上腺素在心肺复苏治疗的疗效及安全性。方法将45例呼吸、心跳骤停患者随机分为两组,对照组(肾上腺素治疗)19例,治疗组(垂体后叶素联合肾上腺素治疗)26例。评估垂体后叶素对心肺复苏治疗的成功率,统计自主循环恢复率,平均自主循环恢复时间,6、24h生存率及出院率。同时监测垂体后叶素对循环、心脏、肾脏的影响,监测患者心率、平均动脉压、复苏成功后30min多巴胺剂量、复苏成功后6h尿量及复苏成功后心电图ST段下移幅度,评估其安全性。结果两组患者在自主循环恢复率、自主循环恢复时间、6h生存率方面比较,差异有统计学意义(P<0.05)。24h生存率及出院率比较,差异无统计学意义(P>0.05);治疗组心率明显低于对照组;两组血压比较无差异,而多巴胺剂量明显高于治疗组;治疗组6h尿量高于对照组;ST段下移无差异。结论在心肺复苏治疗中,垂体后叶素联合肾上腺素可明显提高患者自主心律恢复率,缩短恢复自主心律时间,提高平均动脉压,同时提高冠状动脉及肾脏灌注压,对心脏、肾脏亦是安全的。Objective To study the efficacy and safety of pituitrin combined with adrenaline in the treatment of cardiopulmonary resuscitation. Methods 45 cases of breathing cardiac arrest were randomly divided into two groups, 19 cases in control group（adrenaline）, 26 cases in treatment group（pituitrin combined with adrenaline）. Assessment of pituitrin on the success rate of cardiopulmonary resuscitation, return of spontaneous circulation rate, statistical average return of spontaneous circulation time,6 hours,24 hours survival rate survival rate, discharge rate. Simultaneous monitoring of pituitrin on circulation, cardiac, renal effects, assessment of their safety, the monitoring of patients with heart rate, means arterial pressure, resuscitation was successful after 30 minutes the dopamine, resuscitation was successful after 6 hours urine amount and the electrocardiographic ST segment depression after successful resuscitation rate. Results The restoration of spontaneous circulation rate, restoration of spontaneous circulation time,6 hours of survival in the two groups were statistical significance（P 0.05）;24 hours survival rate and discharge rate was not significantly different（P 0.05）.The influence of heart rate showed that the heart rate comparison of treatment group was significantly lower than the control group; two groups of blood pressure compared with no significant show differences, whereas dopamine dose was significantly low in the treatment group.6 hours urinary volume comparison of treatment group was higher than that of control group.ST segment depression no dramatic differences. Conclusion In cardiopulmonary resuscitation, pituitrin combined with adrenaline can obviously improve the cardiac autonomic cardiac recovery rate, shorten the recovery of autonomic cardiac time, increased mean arterial pressure, while increasing coronary and renal perfusion pressure, heart, kidney is also safe.

关 键 词：垂体后叶素 心肺复苏 肾上腺素 

分 类 号：R459.7[医药卫生—急诊医学]