叶瓜参多糖活性成分的研究  

Studies on the active polysaccharides from Cucumaria frondosa Gunnerus

作　　者：邹峥嵘[1] 陈贝贝[1] 邵俊杰 焦健 易杨华[3] 

机构地区：[1]江西师范大学生命科学院,江西南昌330000 [2]大连海晏堂生物有限公司,辽宁大连116021 [3]第二军医大学药学院海洋药物研究中心,上海200433

出　　处：《中国医药科学》2012年第21期91-92,共2页China Medicine And Pharmacy

基　　金：2010年度国际科技合作项目(2010DFB30810)

摘　　要：目的对叶瓜参中的多糖进行分析。方法应用现代提取分离方法和化学及光谱鉴定技术对多糖成分进行分离鉴定。结果从叶瓜参中分离鉴定了CFG-1、CFG-2和CFG-3等3种多糖成分。结论 CFG-1由木糖、3-甲氧基葡萄糖和葡萄糖组成,其摩尔数比=2︰1︰1;CFG-2由木糖、喹纳糖、3-甲氧基葡萄糖和葡萄糖组成,其摩尔数比=2︰1︰1︰1;CFG-3由喹纳糖和葡萄糖组成,其摩尔数比=1︰1。叶瓜参多糖CFG-2的PTP1B酶活性抑制试验显示,对PTP1B酶具有显著的抑制活性。Objective To analyse the polysaccharides from Cucumber frondosa Gunnerus. Methods Apply modern methods of isolation and spectrum for identification of the polysaccharides. Results 3 of polysaccharides：CFG-1,CFG- 2,and CFG-3 were isolated and identified. Conclusion The CFG-1 was composed of D-xylose,3-O-methyl-D-glucose and D-glucose（mol.rate=2︰1︰1）.CFG-2 was composed of D-xylose,L-quinovose,3-O-methyl-D-glucose and D-glucose （mol. rate=2 ︰ 1 ︰ 1 ︰ 1）. CFG-3 were composed of L-quinovose and D-glucose （mol. rate=1 ︰ 1）. CFG-2 showed significant anti-diabeties activity in the PTP1B inhibition test.

关 键 词：海参 叶瓜参 多糖 抗糖尿病 

分 类 号：Q74[生物学—分子生物学]