进展期胃癌术中区域灌注化疗预防胃癌术后肝脏转移的观察  

Effect of intraoperative artery infusion chemotherapy in advanced gastric cancer in the prevention of postoperative gastric cancer liver metastasis

作　　者：吴江[1] 陈海军[1] 

机构地区：[1]江苏省昆山市中医医院,江苏昆山215300

出　　处：《中国医药科学》2012年第21期188-189,共2页China Medicine And Pharmacy

摘　　要：目的研究进展期胃癌术中肝固有动脉灌注化疗对预防术后胃癌肝转移的作用。方法将2007~2009年医院收治的80例进展期胃癌患者随机分为实验组（n=40,术中区域灌注化疗＋D2根治手术）和对照组（n=40,单纯D2根治手术）,术后常规相同化疗治疗。治疗后随访3年,比较两组患者术后并发症和肝脏转移率。结果两组患者术后并发症的发生率比较差异无统计学意义（P〉0.05）;肝脏转移率实验组明显低于对照组,差异有统计学意义（P〈0.05）。结论进展期胃癌术中区域性动脉灌注化疗可明显降低术后肝脏转移发生率,且不良反应轻,安全可行。Objective To study the value of intraoperative proper hepatic artery infusion chemotherapy for advanced gastric cancer in the prevention of postoperative gastric cancer liver metastasis. Methods 80 cases of advanced gastric cancer patients in our hospital from 2007 to 2009 were randomly divided into experimental group （n=40,intraoperative artery infusion chemotherapy ＋ D2 radical surgery） and control group （n=40,pure D2 radical surgery）, postoperative routine the same chemotherapy treatment. Followed up for 3 years after treatmen,compared the postoperative complications and liver metastasis rate between the two groups. Results There were no statistically significant difference of the incidence of postoperative complications between the two groups（P 0.05）;the liver metastasis rate of the experimental group was significantly lower than the control group（P 0.05）. Conclusion Intraoperative artery infusion chemotherapy in advanced gastric cancer can significantly reduce the postoperative liver metastasis incidence. It is safe and feasible.

关 键 词：进展期胃癌 肝固有动脉 灌注化疗 肝转移 

分 类 号：R735.2[医药卫生—肿瘤]