吉西他滨、亚叶酸钙、氟尿嘧啶联合治疗晚期原发性肝癌32例  

Analysis on gemcitabine,calcium folinate combined with fluorouracil on the treatment of 32 patients with advanced primary liver cancer

作　　者：张康勇 王志飞[1] 孙凤艳[1] 

机构地区：[1]江苏省灌云县人民医院,江苏灌云222200

出　　处：《中国医药科学》2012年第22期74-75,共2页China Medicine And Pharmacy

摘　　要：目的分析吉西他滨、亚叶酸钙、氟尿嘧啶联合治疗晚期原发性肝癌的效果及安全性。方法选择笔者所在医院32例晚期原发性肝癌患者作为观察组,采用吉西他滨、亚叶酸钙、氟尿嘧啶联合治疗;同时选择同期采用对症支持治疗的32例原发性肝癌患者作为对照组,对两组患者近期疗效与远期疗效进行比较,同时观察其不良反应。结果观察组近期疗效及远期疗效明显好于对照组,两组比较差异具有统计学意义(P<0.05)。观察组患者均能耐受治疗,无一例患者因治疗相关性死亡,具有较高的安全性。结论吉西他滨、亚叶酸钙、氟尿嘧啶联合治疗具有不良反应小,患者耐受性好的优点,可延长患者生存期。Objective To analyze the effect and safety of gemcitabine,calcium folinate combined with fluorouracil on the treatment of patients with advanced primary liver cancer.Methods 32 patients with advanced primary liver cancer treated in our hospital were selected as the observation group which were treated with gemcitabine,calcium folinate combined with fluorouracil.32 patients with advanced primary liver cancer applying symptomatic and supportive therapy during the same period were selected as the control group.Comparing the curative effect in the near future and the long term effect between 2 groups,and observing the adverse reactions.Results The curative effect in the near future and of the observation group were better than that of the control group,which had statistical significance（P0.05）.The patients in the observation group all could tolerate the treatment and there was no treatment-related deaths,which had high security.Conclusion The treatment of gemcitabine,calcium folinate combined with fluorouracil has the advantages of fewer adverse reactions and good tolerance for patients and can prolong the survival period of patients.

关 键 词：吉西他滨 亚叶酸钙 氟尿嘧啶 晚期原发性肝癌 效果 

分 类 号：R735.3[医药卫生—肿瘤]