基底细胞样型乳腺癌病理形态特征、免疫表型与分子病理检测的相关性  

Correlation of pathologic morphology,immunophenotype and molecule detection of basal like breast cancer

作　　者：瞿伟 

机构地区：[1]南昌市第三医院病理科,江西南昌330009

出　　处：《中国现代医生》2012年第36期112-114,共3页China Modern Doctor

摘　　要：目的观察基底细胞样乳腺癌(basal-like breast carcinoma,BLBC)的病理形态特征,探讨基底细胞样乳腺癌的免疫表型特点并与之分子检测的相关性。方法对177例BLBC进行形态学观察及免疫组化EGFR、CK5/6检测,再从中挑选10例进行荧光原位杂交(FISH)检测。结果 BLBC是一组组织形态上呈巢片状排列、无腺管形成、大多为推进性边缘、地图样坏死、核分裂象活跃的、组织学几乎均为Ⅲ级、免疫表型ER、PR及C-erbB-2阴性、EGFR和/或CK5/6阳性的乳腺癌;有EGFR基因扩增的患者其淋巴结转移率更高(P<0.05)。结论 BLBC是近年来比较热点的一种新的乳腺癌亚型,具有独特的组织形态特点、免疫组化特征及分子生物学特点,已越来越得到人们的重视和深度认识。Objective To observe the pathologic morphology characteristics of basal like breast cancer carcinoma（BLBC）, and to discuss the correlation of immune phenotype and molecular detection of BLBC. Methods All of 177 cases of BLBC Were observed underwent morphological observation and immunohistochemical detection of EGFR, CK5/6,Then 10 cases were selected to detected byfluorescence in situ hybridization（FISH）. Results The morphology of BLBC was nest schistose arrangement, no glandular tube formation, Mostly the advancing edge, map necrosis, mitotic activity,histology of almost all Ⅲ,and the immune phenotypes of blhc was ER, PR and C-erbB-2 negative,EGFR and/or CK5/6 positive;EGFR gene amplification were associated with higher lymph node metastasis（P 〈 0.05）. Conclusion BLBC is a popular new subtype of breast carcinoma in recent years,with unique histologic features,immunohistochemical and molecular biological characteristics, and it has gained more and more attention and recognition.

关 键 词：乳腺癌 基底细胞样 免疫表型 分子病理 

分 类 号：R737.9[医药卫生—肿瘤]