年轻女性乳腺癌中ER、PR、HER-2和Ki67的表达与临床病理意义研究  

Study of ER、PR、HER-2 and Ki67's expression in young women breast cancer and its clinical pathological meaning

作　　者：施永胜 孙鑫鑫 钟献[3] 

机构地区：[1]浙江省东阳市中医院病理科,浙江东阳322100 [2]浙江省东阳市人民医院病理科,浙江东阳322100 [3]浙江大学医学院附属第二医院肿瘤研究所,浙江杭州310009

出　　处：《中国现代医生》2012年第36期115-116,共2页China Modern Doctor

基　　金：国家自然科学基金(81000945)

摘　　要：目的分析研究ER、PR、HER-2和Ki67在年轻女性乳腺癌中的表达与临床病理意义。方法回顾性分析我院近两年来年轻女性乳腺癌患者资料,随机选取266例女性患者作为实验组;另随机选取266位健康女性作为对照组。取两组患者乳腺内相关组织进行化验,比较两组患者ER、PR、HER-2和Ki67水平。结果对照组的ER、PR水平明显高于实验组;同时,实验组的HER-2水平明显高于对照组。结论年轻女性乳腺癌中HER-2和Ki67与乳腺癌的发生发展呈正相关;ER、PR与乳腺癌的发生发展呈负相关。Objectives To analyze and study ER, PR, HER-2 and Ki67＇s expression in young women breast cancer and its clinical pathological meaning. Methods Retrospectively analyzed those young women patients＇ data （who have been treated at our hospital）, and randomly chose 266 cases of young female patients to form experimental group, and also tan- domly chose 266 cases of healthy women to form control group. Collected two groups＇ patients＇ mammary gland related or- ganization to proceed test, and compared these two groups＇ patients＇ ER,PR,HER-2 and Ki67 level. Results Control group＇s healthy women＇s ER,PR level were obviously higher than experimental group＇s;In the meantime, experimental group＇s patients＇ HER-2 level was obviously higher than control group＇s. Condusion HER-2 and Ki67 in young female breast cancer were positively correlated to breast cancer development; While ER and PR were negatively correlated to breast cancer development.

关 键 词：年轻女性 乳腺癌 ER PR HER-2 KI67 

分 类 号：R737.9[医药卫生—肿瘤]