氦氖激光照射对大鼠实验性牙移动牙周组织中环氧化酶-2表达的影响  

Effect of He-Ne Laser Irradiation on Cyclooxygenase-2 Expression in Periodontium of Experimental Tooth Movement in Rats

作　　者：侯旭[1] 孙秀梅[1] 张超[1] 顾梦婕[1] 张晓英[2] 孙新华[1] 

机构地区：[1]吉林大学口腔医院正畸科,吉林长春130021 [2]吉林大学口腔医院理疗科,吉林长春130021

出　　处：《中国激光》2012年第12期92-96,共5页Chinese Journal of Lasers

摘　　要：为探讨氦氖激光局部照射调控正畸牙移动过程中血管改建的机制,应用波长为632.8nm,激光功率为20mW的氦氖激光照射实验性牙移动大鼠的牙周组织,进而对牙周组织切片进行环氧化酶-2(COX-2)免疫组织化学染色。图像分析结果显示压力区加力3、5、7d组照射侧牙周组织COX-2表达明显高于对照侧,14d后照射侧与对照侧差异无统计学意义;张力区加力1、3、5、7d组照射侧COX-2表达均明显高于对照侧,差异有统计学意义。结果表示氦氖激光照射能增强实验性牙移动大鼠牙周组织中COX-2的表达,参与促进正畸牙移动血管改建的进程。To investigate blood vessel remodeling in the process of He-Ne laser irradition on periodontium of experimental tooth movement, a He-Ne laser with weavelength of 632.8 nm and power of 20 mW is used to irradiate the periodontium of experimental tooth movement in rats. Periodontal slice is treated by cyclooxygenase-2 （COX-2） immunohistochemistry dyeing and the results are obtained by image analysis. The results show that the COX-2 expression in periodontium with forced time of 3, 5, 7 d are significantly higher in experimental side than that of control side in the pressure region. While in the tension region, the COX-2 expression in periodontium with forced time of 1, 3, 5, 7 d are significantly higher in experimental side than that of control side. The results indicate that He-Ne laser can increase COX-2 expression in periodontium during the tooth movement in rats, thus probably enhance the vascularization of tooth movement.

关 键 词：医用光学 牙移动 环氧化酶-2 氦氖激光 牙周组织 免疫组化 

分 类 号：R781.4[医药卫生—口腔医学]