介入热灌注化疗栓塞对肝癌患者血管内皮生长因子的影响  

Effect of Interventional Hyperthermia Chemoembolization on Serum Vascular Endothelial Growth Factor in Patients with Hepatocellular Carcinoma

作　　者：王徽[1] 孙志强[1] 张北光[1] 王纯[1] 

机构地区：[1]吉林省肿瘤医院,吉林长春130012

出　　处：《中国肿瘤》2012年第12期944-946,共3页China Cancer

基　　金：长春市科技局项目(编号:08SF24)

摘　　要：[目的]探讨介入热灌注化疗栓塞对肝癌患者血管内皮生长因子(VEGF)的影响。[方法]采用ELISA方法检测60例原发性肝癌患者(介入热疗组30例和常规介入组30例)治疗前后VEGF的变化,并对两组数据进行对比分析。[结果]治疗前介入热疗组血清VEGF中位值为256.42pg/ml,常规介入组为255.16pg/ml;治疗后1周介入热疗组为179.37pg/ml,较前下降;常规介入组343.58pg/ml,较治疗前升高,两组比较均有显著性差异(P<0.05)。介入热疗组2年生存率(70%)明显高于常规介入组(50%)。[结论]介入热灌注化疗栓塞可抑制VEGF的产生,对减少肿瘤新生血管的形成、防止或降低肿瘤的复发起到积极的作用,其疗效优于常规介入疗法,是治疗中晚期肝癌的一种安全有效的方法。[Purpose] To observe the effect of interventional hyperthermia chemoembolization（IHCE） on serum vascular endothelial growth factor（VEGF） in patients with hepatocellular carcinoma.[Methods] A total of 60 cases with primary hepatocellular carcinoma were divided into two groups：IHCE group（30 cases） and conventional intervention chemoembolization（ICE） group（30 cases）.The levels of VEGF were examined by ELISA method.[Results]Before treatment the median of VEGF was 256.42 pg/ml in IHCE group,while one week after treatment it was 179.37 pg/ml,with significant difference（P0.05）.Before treatment the median of VEGF was 255.16 pg/ml in ICE group,while one week after treatment it was 343.58 pg/ml,with significant difference（P0.05）.The 2-year survival rate in IHCE group（70%） was higher than that in ICE group（50%）（P0.05）.[Conclusion] IHCE inhibits producting VEGF,which plays a positive role in reducing the formation of vascular growth of neoplasm and preventing or reducing the recurrence of neoplasm.It is a safe and effective method in the treatment for advanced hepatocellular carcinoma.

关 键 词：肝肿瘤 介入性热化疗 栓塞 血管内皮生长因子 

分 类 号：R735.7[医药卫生—肿瘤]