经尿道电切联合吡柔比星膀胱灌注与单纯电切治疗腺性膀胱炎的meta分析  

Transurethral electric resection combined with bladder irrigation of Pirarubicin and only transurethral electric resection for cystitis glandularis:a meta analysis

作　　者：王厚清[1] 刘修恒[1] 肖腾飞[1] 

机构地区：[1]武汉大学人民医院泌尿外科,武汉430060

出　　处：《临床急诊杂志》2012年第6期407-410,413,共5页Journal of Clinical Emergency

摘　　要：目的:评价经尿道电切联合吡柔比星膀胱灌注与单纯电切治疗腺性膀胱炎的疗效和安全性。方法:依据循证医学原则,用Cochrane系统评价方法,检索2005年-2011年期间中国知识资源总库,中国生物医学文献数据库,万方,重庆维普数据库等,纳入经尿道电切联合经尿道电切联合吡柔比星膀胱灌注膀胱灌注与单纯电切治疗腺性膀胱炎的疗效和安全性的随机对照实验(RCT),采用RevMan5.1软件行meta分析。结果:纳入10个RCTS,共809例患者。根据Cochrane系统评价体系,结果质量均达B级。meta分析结果:经尿道电切联合吡柔比星膀胱灌注组患者随访1年腺性膀胱炎复发率比单纯电切治疗组低(OR=0.43,95%CI0.30～0.60,P<0.05)。灌注吡柔比星后出现膀胱刺激征和血尿与单纯电切组存在明显差异(OR=1.07,95%CI1.03～2.82,P<0.05),(OR=1.35,95%CI0.64～2.82,P<0.05)。结论:经尿道电切联合吡柔比星膀胱灌注能有效的防止腺性膀胱炎的复发,但其诱发的膀胱刺激征和血尿的发生率明显高于单纯电切。Objective：To evaluate the disparity of the efficiency and safety between transurethral electric resection combined with bladder irrigation of Pirarubicin and only transurethral electric resection for cystitis glandularis.Method：Based on the principles of evidence-based medicine,with the Cochrane systematic review methods,we searched PUBMED,CNKI,CBM,Wanfang-data,Chongqing-VIP database and so on in the period of 2005to 2011,and collected the RCTS of efficiency and safety of transurethral electric resection combined with bladder irrigation of Pirarubicin and only transurethral electric resection for cystitis glandularis.The studies were retrieved for a meta analysis using RevMan 5.1software.Result：10RCTS,including 809patients,were collected to meet the requirements of the RCT study.According to the randomization,allocation concealment,blinding,losing,the level of baseline,the line quality of comparison and description and the assessment of the included studies and so on,the results of the quality of all was up to Grade-B.The meta analysis showed that：the followed up 1years recurrence rate of cystitis glandularis of transurethral electric resection combined with bladder irrigation of Pirarubicin was lower than that of only transurethral electric resection,（OR=0.43,95%CI 0.30～0.60,P0.05）.The difference of incidence of bladder irritation and hematuria after transurethral electric resection combined with bladder irrigation of Pirarubicin and only after transurethral electric resection was statistically significant（OR=1.07,95%CI 1.03～2.82,P0.05）,（OR=1.35,95%CI 0.64～2.82,P0.05）.Conclusion：Transurethral electric resection combined with bladder irrigation of Pirarubicin was recommended to prevent the recurrence of cystitis glandularis.but it can＇t lower the incidence of the bladder irritation and hemaruria.

关 键 词：腺性膀胱炎 吡柔比星 经尿道腺性膀胱炎电切术 META分析 

分 类 号：R741[医药卫生—神经病学与精神病学]