神经传递与β-淀粉样蛋白前体的加工调控  

Neurotransmission and regulation of amyloid protein precursor processing

作　　者：殷明[1] 杨德刚[1] 

机构地区：[1]第二军医大学药学院药理学教研室,上海200433

出　　处：《中国药理学通报》1999年第6期481-484,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金!No 39770849 ;No 39770807

摘　　要：淀粉样蛋白沉积是阿尔采末病（Ａｌｚｈｅｉｍｅｒｓｄｉｓｅａｓｅ，ＡＤ）中重要的组织病理学特征，其前体ＡＰＰ在加工代谢过程中生成两类作用相反的产物。有些神经递质受体参与调控这一加工过程，提示神经传递活动在ＡＤ发生发展机制中起了作用。Amyloid deposit is an important characteristic of the histopathology in Alzheimers disease(AD). The products of the amyloid protein precursor (APP) during cellular processing can be divided into two contradictory effect groups. Some neurotransmitters can regulate APP processing suggesting that agents affecting some neurotransmission may influence the pathogenesis of AD.

关 键 词：淀粉样蛋白 神经递质 早老性痴呆 

分 类 号：R749.160.2[医药卫生—神经病学与精神病学]