影响头孢克罗缓释片释药因素的研究  

The Factors Influencing on Cefaclor Release From Sustained Release Tablets

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作  者:尹莉芳[1] 屠锡德[1] 李欣[1] 

机构地区:[1]中国药科大学药剂学教研室,南京210009

出  处:《中国药科大学学报》1999年第6期417-419,共3页Journal of China Pharmaceutical University

摘  要:以 HPMC为缓释材料 ,采用湿法制粒制备缓释片 ,用体外释放度试验研究了缓释片的释药机理及影响因素。结果表明 ,缓释片的释放符合 Higuchi方程 ,HPMC的粘度、用量、丙烯酸树脂 号的用量。Cefaclor sustained-release tablets were prepared with wet methods, the mechanism and the influencing factors on drug release were studied through the releasing tests. The results showed that the drug releasing rate from the tablets followed Higuchi equation and the effects of HPMC viscosity, content, Eudragit L100 content, pressure on cefaclor release were significant.

关 键 词:头孢克罗 缓释片 释药速率 HPMC 

分 类 号:R978.11[医药卫生—药品]

 

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