细胞因子的变化与宫颈癌、宫颈上皮增生病变临床关系的探讨  

Variation of Cytokine Levels in Patients with Cervical Carcinoma and Cervical Epithelial Proliferative Lesion and Its Clinical Significance

作　　者：钟述猷[1] 宋学茹[2] 阎欢[1] 符磊[1] 邢娜[1] 李昭[2] 

机构地区：[1]天津医科大学总医院免疫科,300052 [2]天津医科大学总医院妇科,300052

出　　处：《天津医药》2000年第1期14-16,共3页Tianjin Medical Journal

摘　　要：应用双抗体夹心ELISA法测定110例宫颈上皮增生病变和30例宫颈癌患者TNFα、sIL-2R、IL-6和IL-8的含量。结果:宫颈上皮增生病变各组患者TNFα、sIL-2R、IL-6和IL-8水平均明显高于对照组(均P<0.01),且随宫颈上皮病变程度的加重而相应地升高。宫颈癌组细胞因子变化的特点:(1)TNFα和sIL-2R水平增高显著,与宫颈上皮内瘤样病变(CIN)各病变组有明显差异(均P<0.01)。(2)IL-6和IL-8水平未见明显改变。表明细胞因子的变化与宫颈上皮增生病变的进展以及宫颈癌患者的免疫抑制状态相关。因此,细胞因子的测定对于宫颈癌的早期辅助诊断和预后的判断有重要的临床意义。Methods:The levels of serum TNF-α,sIL-2R, IL-6 and IL-8 in 110 patients with cervical epithelial lesion and 30 with cervical carcinoma were measured by using double-antibody sandwich ELISA. Results: The levels of TNF-α,sIL-2R, IL-6 and IL-8 in every subgroups with cervical epithelial proliferation were obviously higher than those of control group (P< 0.01) ,and the levels were increased with the severity of the lesions. Cytokines levels in cervical carcinoma group had two characteristics: (l)TNF-α and SIL-2R markedly elevated,and had significant difference compared with other groups (P< 0.01);(2)Levels α of IL-6, IL-8 had no significant difference,it suggested that the secretion of IL-6,IL-8 were suppressed in cervical carcinoma. Conclusion: Changes of cytokines were closely linked to cervical epithelial proliferative progress and cervical carcinoma immune-suppression status. The cytokine determination may have great clinical significance of early diagnosis and prognosis prediction of cervical carcinoma.

关 键 词：细胞因子 宫颈上皮增生 CIN TNF 宫颈癌 

分 类 号：R737.330.2[医药卫生—肿瘤]