大鼠牙周组织中肿瘤坏死因子—α受咬合力丧失影响变化的研究  

Effect of lost bite force on the expression of TNF-α in the rat periodontium

作　　者：袁林[1] 赵云凤[1,2] 周伟东 

机构地区：[1]华西医科大学口腔医学院,成都610041 [2]第一军医大学珠江医院

出　　处：《临床口腔医学杂志》2000年第2期69-70,共2页Journal of Clinical Stomatology

摘　　要：检测咬合力在正常及丧失状态下 ,大鼠牙周细胞 TNF— α的动态表达 ,初探 TNF— α在牙周组织改建中的分子机理。方法　采用 HE染色和免疫组化的方法 ,观察牙周形态变化以及牙周组织中 TNF— α蛋白表达。结果　咬合力丧失引起牙周膜结构紊乱、牙槽骨吸收。同时 ,牙周细胞中 TNF— α表达较正常咬合力时明显增强。结论　咬合力丧失 ,促使 TNF—α明显增多。本实验从分子水平探讨了牙周组织改建的机理 ;揭示了牙周组织结构与功能在改建中的一致性。Objective To study the expression of TNF-α in the rat periodontal cells under normal and lost bite force, in order to explain the molecular mechanism of periodontium remodeling. Methods HE staining and immunohistochemistry techniques were applied to study the change in the histologic morphology and the expression of TNF-α protein. Results Under the lost bite force, periodontal ligament structure was disorganized and alveolar bone was absorbed; the expression level of TNF-α increased apparently in periodontal cells.Conclusion Lost bite force induce the expression of TNF-α increased apparently in periodontium. It approached initially the molecular mechanism of periodontium remodeling, suggested that the histologic morphology is closely related to the mechanical condition.

关 键 词：咬合力 肿瘤坏死因子Α 牙周组织改建 

分 类 号：R781.402[医药卫生—口腔医学]