单纯疱疹病毒I型在RAU发生中的作用探讨  

The role of HSV-1 in the Pathogenesis of RAU.

作　　者：耿海霞[1] 李辉菶[2] 范崇德[2] 

机构地区：[1]济宁医学院附属医院,济宁272129 [2]湖北医科大学附属二医院

出　　处：《临床口腔医学杂志》2000年第2期99-100,共2页Journal of Clinical Stomatology

摘　　要：本研究采用 PCR技术分别对 42例 RAU患者、2 8例 OL P患者和 30例正常人口腔脱落细胞中 HSV- 1DNA进行检测 ,结果显示 :RAU组 HSV- 1DNA阳性率 42 .86 % ,与 OL P病例对照组 7.14%及正常对照组 6 .6 7%比较 ,均有显著性差异 (P<0 .0 0 5 ) ;不同性别、年龄、型别的 RAU患者口腔脱落细胞 HSV- 1DNA的阳性率无显著性差异 (P>0 .0 5 )。提示 HSV- 1在 RAU发生中具有重要作用。The objective of this study was to investigate the role of HSV 1 in the pathogenesis of RAU. PCR was used to detect HSV 1 DNA in oral mucosal smeared cells from 42 RAU patients, 28 OLP patients and 30 healthy controls respectively. The positive rate of HSV 1 DNA was 42.86% in RAU patients, whereas only 7.14% in OLP controls and 6.67% in normal controls. Significant difference was found between the RAU patients and two controls repectively( P <0 005). But there was no significant difference between the HSV 1 DNA positive rate from RAU patients of different sexes and ages. The results proved that HSV 1 existed in RAU patients, and suggested HSV 1 may play an important role in the pathogenesis of RAU.

关 键 词：RAU 复发性口疮 单纯疱疹病毒Ⅰ型 

分 类 号：R781.59[医药卫生—口腔医学]