血管内皮生长因子C水平对膀胱癌诊断和预后评估的临床价值  

Clinical Significance of the Level of Vascular Endothelial Growth Factor-C in Diagnosis and Prognosis of Patients with Bladder Cancer

作　　者：梁彬[1] 郭政东[1] 李云慧[2] 

机构地区：[1]中国医科大学高等职业技术学院,沈阳110001 [2]解放军第202医院检验科,沈阳110003

出　　处：《临床误诊误治》2012年第12期52-54,共3页Clinical Misdiagnosis & Mistherapy

基　　金：辽宁省自然科学基金资助项目(201102279)

摘　　要：目的探讨血清血管内皮生长因子C(vascular endothelial growth factor-C,VEGF-C)水平与膀胱癌发生发展、复发转移和预后的关系。方法选择71例经病理确诊的膀胱癌患者为膀胱癌组,同期健康体检者50例为对照组,采用酶联免疫吸附方法测定两组血清VEGF-C水平并进行比较。结果膀胱癌组血清VEGF-C水平为1.4～42.2μg/L,对照组为0.2～12.6μg/L,差异有统计学意义(P<0.01)。膀胱癌组血清VEGF-C水平与淋巴结转移、淋巴管浸润、血管浸润和复发相关,差异有统计学意义(P<0.05);与临床分期和病理分期无相关性(P>0.05)。血清VEGF-C诊断膀胱癌的灵敏度为81.7%,特异度为72.0%。血清高VEGF-C水平的膀胱癌患者的生存率显著降低,与低VEGF-C水平者比较差异有统计学意义(P<0.05)。结论血清VEGF-C测定可作为膀胱癌早期诊断和判断预后的指标。Objective To explore the relationship between the level of vascular endothelial growth factor-C with the development,recurrence,metastasis and prognosis of bladder cancer.Methods Levels of serum VEGF-C were detected and compared between 71 patients with bladder cancer by pathology diagnosis（bladder cancer group） and 50 healthy controls（control group）.Results The serum level of VEGF-C in bladder cancer group（1.4~42.2 μg/L） was significantly higher than that of in control group（0.2~12.6 μg/L）（P0.01）.The serum level of VEGF-C in bladder cancer group was related to lymph nodes metastasis,lymphovascular invasion,vascular infiltrating and recurrence,and the differences were statistically significant（P0.05）;but the serum level was not related to clinical stages and pathological stages（P0.05）.Sensitivity and specificity of serum VEGF-C in diagnosis of bladder cancer were 81.7% and 72.0% respectively.The survival rate in patients with high VEGF-C levels was significantly lower than those with low VEGF-C levels in bladder cancer patients（P0.05）.Conclusion Detection of serum VEGF-C is a useful marker in diagnosis and prognosis of bladder cancer.

关 键 词：血管内皮生长因子C 膀胱癌 诊断 预后 

分 类 号：R737.14[医药卫生—肿瘤]