马衔山黄芪水提物抗肿瘤转移及生长初步研究  

Study on Anti-tumor Metastasis and Anti-tumor Growth Effects of Water Extract from Astragalus mahoschanicus

作　　者：杜文静[1] 魏育才[1] 董信芳[1] 崔芬芬[1] 沈世林[1] 

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000

出　　处：《中国野生植物资源》2012年第6期24-27,52,共5页Chinese Wild Plant Resources

基　　金：2011年兰州大学学生创新创业行动计划项目(597号)

摘　　要：目的:研究马衔山黄芪对转移性肝癌的抑制及其生长影响。方法:经尾静脉接种H22肝癌细胞悬液建造肿瘤转移小鼠模型后,随机分为6组。1 d后,分别以生理盐水,环磷酰胺,低、中、高剂量马衔山黄芪水提物以及马衔山黄芪水提物合并环磷酰胺处理20 d后,处死小鼠测定体重、胸腺及脾脏重量以及巨噬细胞吞噬率,观察小鼠肺部转移瘤生长情况。结果:马衔山黄芪低、中、高剂量组以及马衔山黄芪合并环磷酰胺(CTX)组的瘤结节数少于N.S组,马衔山黄芪中、高剂量组的胸腺、脾脏指数,腹腔巨噬细胞吞噬率高于N.S组。结论:马衔山黄芪具有免疫调节功能,对肿瘤转移和生长有抑制作用。To study the inhibition and growth effects of Astragalus mahoschanicus on metastatic liver cancer. Methods： Established the tumor metastasis mouse model by injecting H22 hepatoma cell suspension to tail vein, divided into 6 groups randomly, one day later, treated with saline, CTX, low, medium, high doses Astragalus mahoschanicus, and Astragalus mahoschanicus combined with CTX respectively for 20 days. Then sacrificed mouse, measured body weights, spleen weights and thymus weights, calculated phagocytosis rate of macrophages, observed the growth of metastatic carcinoma in lung. Results Compared with the saline group, the number of metastatic nodules in lung was decreased in Astragalus mahoschanicus high-dose, middle-dose, low-dose groups and Astragalus mahoschanicus cornbined with CTX group. The spleen index, thymus index and the phagocytosis rate of macrophages were increased in high-dose, middle-dose groups. Conclusion： Astragalus mahoschanicus can inhibit tumor metastasis and growth, and can regulate immune function.

关 键 词：马衔山黄芪 H22 转移 生长 

分 类 号：R730.52[医药卫生—肿瘤]