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机构地区:[1]上海铁道大学医学院附属铁路医院呼吸内科,上海200072 [2]南京铁道医学院附属医院,南京210009
出 处:《上海铁道大学学报》2000年第1期50-62,共13页
基 金:铁道部科技基金资助课题! ( J97TW77)
摘 要::目的 通过对肺癌组织雌 /孕激素受体表达的测定 ,从病理特征、超微结构及内分泌治疗方面进行初步探讨。方法 应用免疫组织化学 SP法检测 40例肺癌和 10例肺良性病变组织雌 /孕激素受体表达 ,并结合临床病理、超微结构 ,部分肺癌患者辅以三苯氧胺治疗。结果 肺癌组织中雌激素受体 (estrogen receptor,ER)阳性率为5 7.5 % ,孕激素受体 (progesterone receptor,PR)阳性率为 40 .0 % ,受体阳性率与组织学分级呈负相关 ,且与病理类型有关 ,与分期、肿块直径、性别无关 ;电镜亦证实 ER阴性者更具恶性特征 ;三苯氧胺对 ER阳性肺癌患者有效。结论 肺癌组织中存在雌 /孕激素受体的表达 ,并能反映肺癌的生物学行为 ;三苯氧胺对Objective To investigate the clinical significance of estrogen/progesterone receptor (ER/PR) expressions in lung cancer and its endocrine treatment.Methods ER/PR were detected in 40 lung cancer specimens with immunochemistry method. Its relations to biologic feature and ultrastructure were analysed. Parts of the patients were treated with tammoxipon.Results The positive rates of ER and PR in lung cancer specimens were 57.5% (23/40) and 40.0% (16/40), respectively. The positive rate had a negative correlation to histopathologic grade and were related to the pathological classification (P<0.05), but not related to the size of tumor, clinical stages and the sex of patients. The ultrastructural changes showed the ER positive lung cancers had less malignant biologic behavior than that of the ER negative. Tamoxipon was effective in the treatment of lung cancer especially to those ER positive.Conclusion The presence of ER/PR in lung cancer cells can reflect its biologic behavior and provide base for its clinical endocrine treatment.
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