重性抑郁障碍与双相障碍患者的共病研究  

A comorbidity survey of major depressive disorder and bipolar disorder

作　　者：肖春兰[1] 方贻儒[2] 汪作为[1] 黄乐萍[1] 王亚光[1] 朱光[1] 介勇[1] 蒋学萍[1] 罗碧明[1] 

机构地区：[1]上海市虹口区精神卫生中心,200083 [2]上海市精神卫生中心

出　　处：《临床精神医学杂志》2012年第6期372-374,共3页Journal of Clinical Psychiatry

基　　金：上海市医学重点专科建设计划项目(ZK2012A12);上海市虹口区医学重点专科建设项目(虹卫[2010]91号);上海市虹口区卫生局青年业务骨干临床导师制培养(虹卫[2010]16号);上海市虹口区卫生系统科研立项课题(虹卫1004-30号)

摘　　要：目的:调查重性抑郁障碍(MDD)和双相障碍患者(BD)精神科共病情况。方法:采用横断面调查方法,对2011年3月至8月符合美国精神障碍诊断与统计手册第4版(DSM-Ⅳ)诊断标准的141例重性抑郁障碍和52例双相障碍患者进行一般情况问卷及国际神经精神科简式访谈问卷(MINI)调查。结果:重性抑郁障碍组和双相障碍组精神科共病率分别为30.0%和28.8%,两组共病率差异无统计学意义(χ2=0.016,P>0.05);两组共病焦虑障碍最为常见,其共病率分别为27.0%和15.4%,差异无统计学意义(χ2=2.799,P=0.094);共病酒精依赖或物质滥用差异有统计学意义(χ2=6.405,P=0.011)。结论:重性抑郁障碍和双相障碍与其他精神科疾病存在广泛共病,尤以焦虑障碍多见。Objective：To investigate the psychiatric comorbidity of major depressive disorder（MDD） and bipolar disorder（BD）patients.Method：A cross-sectional investigation was conducted on the comorbidity from March 2011 to August 2011;and 141 patients with MDD and 52 patients with BD were assessed with questionnaire and mini-international neuropsychiatric interview（MINI）.Results：MDD and BD patients with psychiatric comorbidity rate was 30.0% and 28.8% respectively（χ2=0.016,P0.05）.The most common comorbidity was anxiety disorders,and the comorbidity rate was 27.0% and 15.4% respectively（χ2=2.799,P=0.094）.There was statistically differences in comorbidity rate of alcohol dependence and substance abuse between MDD group and BD group（χ2=6.405,P=0.011）.Conclusion：MDD and BD have a extensive comorbidity,especially comorbid anxiety disorders.

关 键 词：重性抑郁障碍 双相障碍 共病 

分 类 号：R749.4[医药卫生—神经病学与精神病学]