早发型单相抑郁症患者遗传方式的研究  

A study of genetic model in early-onset unipolar depression

作　　者：祁曙光[1] 董小惠[1] 张云彪[1] 张国富[1] 

机构地区：[1]无锡市精神卫生中心精神科,江苏214151

出　　处：《临床精神医学杂志》2012年第6期397-399,共3页Journal of Clinical Psychiatry

摘　　要：目的:探讨早发型单相抑郁症患者的遗传方式。方法:采用严格的纳入标准,对符合中国精神障碍分类与诊断标准第3版抑郁发作诊断标准、首次发病年龄≤30岁的47例单相抑郁症患者采用医学遗传数学方法中分离分析和多基因阈值理论进行遗传方式的探讨。结果:早发型一级亲属单相抑郁症加权平均遗传率及标准误为(96.3±1.3)%;预期发病率为9.37%,与实际发病率7.94%相比较差异无统计学意义(u=0.7814,P>0.05)。结论:早发型单相抑郁症患者遗传方式符合多基因遗传。Objective：To explore the mode of inheritance of early-onset unipolar depression.Method：The families of 47 subjects who met diagnostic criteria of Chinese classification and diagnostic criteria for mental disorders third edition and whose first depressive episode begins no later than 30 years were studied by segregation analysis and polygenic threshold theory.Results：The weighted mean of the heritability and standard error was（96.3±1.3）%.The expected incidence was 9.37%,showing no significant difference compared with the first-degree relatives＇ incidence of 7.94%（u=0.7814,P0.05）.Conclusion：The findings suggest that the mode of inheritance of early onset unipolar depression was in conformity to multifactorial inheritance.

关 键 词：单相抑郁症 遗传方式 

分 类 号：R749.4[医药卫生—神经病学与精神病学]