VEGF和p53在肝细胞性肝癌组织中的异常表达与预后的关系  

Abnormal Expression of VEGF and p53 in Hepatocellular Carcinoma Tissues and Correlation with Prognosis of HCC

作　　者：郭晓东[1] 张苧月 赵景民[1] 熊璐[1] 周光德[1] 赵雨来[1] 

机构地区：[1]解放军第302医院 [2]总后丰台综合仓库(62370部队)药材供应站

出　　处：《现代生物医学进展》2012年第33期6451-6453,共3页Progress in Modern Biomedicine

基　　金：国家"十二五"科技重大专项课题(2012ZX10002-003)

摘　　要：目的:探讨VEGF和p53在肝癌组织中表达与肝癌预后的关系,为肝癌的防治提供新的思路。方法:回顾性分析了2006年1月到2009年8月收治的40例肝癌患者的临床资料,采用免疫组织化学法测定肝癌组织、癌旁组织和正常组织中VEGF和p53的表达。结果:VEGF和p53阳性表达率在肝癌组分别为62.5%和47.5%,癌旁组分别为22.5%和2.5%,在正常组未检测到VEGF和p53阳性表达,三组之间比较有显著性差异(P<0.05);本组40例肝癌患者术后均获随访,22例复发;复发组患者癌组织中VEGF和p53的阳性表达率均高于未复发组,相比较有显著性差异(P<0.05)。结论:在肝癌组织中存在VEGF和p53的异常表达,VEGF和p53异常表达与肝癌的预后密切相关。Objective： To investigate the abnormal expression of VEGF and p53 in hepatocellular carcinoma （HCC） tissues and correlation with prognosis of HCC. Method： The clinical data of patients with pimary liver cancer was retrospectively analyzed from January 2006 to August 2009. The VEGF and p53 expression in HCC tissues, cancer tissue and normal tissue were detected by immunohistochemistry method. Results： The VEGF and p53 expression rate in HCC group were 62.5 % and 47.5%, the adjacent group were 22.5 % and 2.5%, in the normal group did not detect p53 expression, compared the difference among the three groups were significant （P〈0.05）;All HCC patients were followed up, of which 22 patients relapsed; the VEGF and p53 expression in recurrent HCC tissues were higher than the without recurrence group, and the difference was significant （P 〈0.05）. Conclusion： There is abnormal expresion of VEGF and p53 in the HCC tissues, the abnormal expresion of VEGF and P53 is closely related to prognosis of HCC.

关 键 词：肝癌 抑癌基因 VEGF P53 免疫组化 

分 类 号：R735.7[医药卫生—肿瘤]