硝酸酯类药物及钙离子拮抗剂对胃食管反流的影响  

The Influence of Nitrates and Calcium Antagonists for Gastroesophageal Reflux Disease

作　　者：程远[1] 蓝宇[1] 李笠[1] 贾绮宾[1] 

机构地区：[1]北京积水潭医院消化内科,北京100035

出　　处：《现代生物医学进展》2012年第33期6496-6498,共3页Progress in Modern Biomedicine

摘　　要：目的:探讨硝酸酯类药物及钙离子拮抗剂对胃食管反流症状的影响。方法:选取2010年1月-2011年1月我院收治的心血管病患者99例,根据服用药物不同分为三组:单独使用硝酸酯类药物组35例;单独使用钙离子拮抗剂组31例;以及对照组(既无硝酸酯类药物也无钙离子拮抗剂)33例。比较三组患者胃食管反流症状积分。结果:单纯使用硝酸酯类药物组比其他药物组及钙离子拮抗剂组的病人在早饱、恶心和呕吐的症状积分上较高并存在明显差异(P<0.05)。钙离子拮抗剂组与硝酸酯类药物组比较烧心症状积分较高并有统计学上明显差异(P<0.05)。钙离子拮抗剂组与其他药物组比较烧心及返酸积分较高,但差异无统计学意义(P>0.05)。结论:硝酸酯类药物在早饱、恶心、呕吐几方面比使用其他类药物更多地引起症状。钙离子拮抗剂似乎更易引起反酸、烧心等胃食管反流症状,但未得到证实。Objective： To study the influence of nitrates and calcium antagonists for gastroesophageal reflux symptom. Methods： From January 2010 to January 2011, 99 cases of patients with cardiovascular disease were divided into three groups according to the drug used： 35 cases of patients were in the nitrates group; 31 cases of patients were in the calcium antagonists group and 33 cases of patients were in the control group （ neither nitrates nor calcium antagonists ）. The gastroesophageal reflux symptoms score of three groups were compared. Results： The score of early full feeling, nausea and vomitthe symptoms in the nitrates group were higher than those in the other drug groups and calcium antagonists group, and the difference were significant （P〈0.05）. The score of heartburn in the calcium antagonists group was higher than that in the nitrates group, and the difference was significant （P〈0.05）. The score of heartburn and sour regurgitation was higher in the calcium antagonists group than in the other group, but with no significant difference （P〉0.05）. Conclusion： The nitrates can cause greater symptoms such as the early full feeling, nausea and vomiting than any other drugs. The calcium antagonist seems to be much easier to cause the gastroesophageal reflux symptoms like heartburn and sour regurgitation, but not yet confirmed.

关 键 词：硝酸酯类药物 钙离子拮抗剂 胃食管反流病 下食道括约肌 

分 类 号：R571.1[医药卫生—消化系统]