兰索拉唑治疗胃食管反流病的临床疗效及食管功能变化观察  

Curative Effect and Reflux Laryngitis and the Motor Activity of Esophagus of Lansoprazole in Treatment of Gastroesophageal Reflux Disease

作　　者：张静[1] 桑海彤[1] 王燕[1] 张凯[1] 周瑞林[1] 段莎[1] 薛辉[1] 

机构地区：[1]解放军第323医院干部病房消化科,陕西西安710054

出　　处：《现代生物医学进展》2012年第33期6532-6535,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨兰索拉唑治疗胃食管反流病的临床疗效,并观察食管功能变化。方法:回顾性分析我院2009年10月-2012年5月收治的GERD患者500人,根据治疗方法不同分为分为兰索拉唑组和法莫替丁组,比较两组的治疗效果;并采用超声内镜测定食管运动功能的在服药前后的变化。结果:兰索拉唑组有效率为89.2%,法莫替丁组有效率为78.4%,二者进行比较,X2=16.850,P<0.05,差异有统计学意义。兰索拉唑组与法莫替丁组治疗Ⅰ级、Ⅱ级、Ⅲ级和Ⅳ级胃食管反流病效果比较,P均<0.05,差异有统计学意义(X2=3.943,X2=5.223,X2=4.028,X2=3.988)。兰索拉唑组顶端收缩指数、收缩周期、顶端被动扩张管腔的最大截面积与法莫替丁组比较,P均<0.05,差异有统计学意义(t=4.271,t=3.982,t=4.028)。兰索拉唑组的不良反应发生率为4.8%,法莫替丁组不良反应发生率为13.6%,两组不良反应发生率比较,X2=11.588,P<0.05,差异有统计学意义。结论:兰索拉唑治疗胃食管反流病效果良好,不良反应发生率低,安全性高,适应临床应用。Objective： To investigate the relationship between gastroesophageal reflux disease （GERD） and reflux laryngitis and the motor activity of esophagus. Methods： A retrospective analysis of 500 patients with gastroesophageal reflux disease in our hospital from Jan. 2009 to May. 2012 were divided into 2 groups according to the ways of treatment. The clinical effects and oral cavity function were compared between the two groups. Results： The effective rate of lansoprazole was 89.2%, famotidine was 78.4%, X^2=16.850, P〈 0.05, there were statistically significant difference. The clinical effects for Ⅰ （ X^2=3.943, P 〈 0.05 ）, Ⅱ （ X^2=5.223, P 〈 0.05 ）, Ⅲ （ X^2=4. 028, P 〈 0.05 ）and Ⅳ （X^2=3.988, P 〈 0.05 ）of lansoprazole and famotidine were statistically different. CI （t=4.271, P 〈 0.05 ）, DC （t=3. 982, P 〈 0.05）, DSA for top （t=4.028, P 〈 0.05 ）for lansoprazole and famotidine were statistically different. The incidence rate of adverse drug reactions （ADR）of lansoprazole was 4.8% and famotidine was 13.6%. There were statistically significant difference （ X^2=11.588, P〈0.05）. Conclusion： The clinical effects for lansoprazole for GERD is perfect and safe, it has great value in clinical application.

关 键 词：兰索拉唑 胃食管反流病 食管功能 疗效 

分 类 号：R571[医药卫生—消化系统]