术前血清CEA在结直肠癌患者预后判断上的作用  

Prognostic Significance of Preoperative Serum CEA in Patients with Colorectal Cancer

作　　者：胡书生[1] 王慜杰[1] 高佳[1] 齐军[1] 

机构地区：[1]北京协和医学院中国医学科学院肿瘤医院检验科,北京100021

出　　处：《标记免疫分析与临床》2012年第6期333-337,共5页Labeled Immunoassays and Clinical Medicine

摘　　要：目的研究术前血清癌胚抗原(CEA)在判断结直肠癌患者预后中的价值。方法 426例结直肠癌患者按术前CEA水平分为两组:CEA正常组(﹤5ng/mL)和CEA升高组(≥5ng/mL)。跟踪随访上述病例并分析相关临床病理学指标同预后的关系。结果术前血清CEA水平与结直肠癌患者肿瘤大小、浸润深度、淋巴结转移及临床分期密切相关。血清CEA升高组患者的总生存期和无进展生存期明显低于CEA正常组(P<0.001,P<0.001)。单因素及多因素回归分析证明,术前血清CEA水平为判断结直肠癌患者预后的独立指标。结论血清CEA可为结直肠癌患者预后判断提供重要的临床参考依据。Objective To evaluate the prognostic value of the preoperative serum careinoembryonie antigen （CEA） level in patients with colorectal cancer （CRC）. Methods 426 patients who underwent potentially cura- tive resection for non-metastatic colorectal cancer in our hospital comprised were involved in this study. All patients were categorized into two groups according to the preoperative serum CEA level： normal CEA （〈5ng/mL） and elevated CEA （≥5ng/mL） and patients were followed up intensively. The clinicopathologic features of these patients were retrospectively investigated and prognostic factors were evaluated. Results The ele- vated serum CEA level was related to tumor diameter, T category, lymph invasion and TNM stage. Elevated ser- um CEA levels before therapy were significantly correlated with a poorer overall survival （OS）and disease-free survival（PFS） （P 〈 0.001 ）. In univariate and multivariate regression analysis, serum CEA level was an independent predictor for OS and PFS in patients with colorectal cancer. Conclusion The results demonstrated that preoperative serum CEA seem to be a promising factor to predict the outcome of patients with colorectal cancer.

关 键 词：结直肠癌 癌胚抗原 预后 

分 类 号：R735.35[医药卫生—肿瘤]