STAT5在造血调控及相关血液疾病发生中的作用  

Roles of STAT5 in Hematopoietic Regulation and Blood Diseases——Review

作　　者：赵云泽 袁卫平 程涛 

机构地区：[1]中国医学科学院、北京协和医学院血液学研究所、血液病医院,实验血液学国家重点实验室,中国医学科学院干细胞医学中心,天津300020

出　　处：《中国实验血液学杂志》2012年第6期1496-1500,共5页Journal of Experimental Hematology

基　　金：科技部重大国际合作:(编号2010DFB30270);国家自然科学基金(编号81090411,30825017,90913018,81130074,81070390,30971110)

摘　　要：信号转导与转录活化因子5(STAT5)是一种广泛存在于多种组织细胞胞浆内的转录因子,在被激活后能够进入细胞核与特异性DNA序列结合,从而发挥转录调控作用。STAT5有STAT5A和STAT5B两种异构体,二者具有96%的同源性,但其生理功能并不完全相同。研究显示,STAT5能够调节造血细胞的生存、增殖、分化和凋亡,它的过度激活与多种血液系统恶性疾病的病理发生过程密切相关,所以STAT5在临床上可能成为一个新的治疗靶点。本文就该分子在造血调控及相关血液疾病中发挥的作用加以阐述。Signal transducer and activator of transcription 5 （STAT5） is an important transcription factor existing in the cytoplasm of various types of cells. Once activated, STAT5 dimers translocate into nucleus and bind to the corresponding DNA sequence to regulate the transcription of its target genes. There are two isoforms of STATS： STAT5A and STAT5B with 96% sequence homology and are encoded by two closely related but different genes. Studies have shown that STAT5 can regulate the survival, proliferation, differentiation and death of hematopoietic cells. Furthermore, elevated activation of STAT5 was found in many malignant hematologic diseases and therefore raised the possibility that STAT5 may be used as a new therapeutic target for blood related diseases. This review discusses the regulatory role of STAT5 in hematopoietic cells and its effect on the occurrence and development of blood diseases.

关 键 词：STAT5 造血调控 造血干细胞 恶性血液病 

分 类 号：R733.7[医药卫生—肿瘤]