MOG抗体在不同类型免疫介导性视神经炎血清中的表达  

Anti-MOG antibody in different types of immune-mediated optic neuritis

作　　者：孔秀云[1] 彭静婷[1] 刘丽娟[2] 颜榕[1] 张晓君[1] 

机构地区：[1]首都医科大学附属北京同仁医院神经内科,100730 [2]北京同仁眼科中心北京市眼科研究所北京市眼科学与视觉科学重点实验室

出　　处：《中华眼科杂志》2012年第12期1069-1072,共4页Chinese Journal of Ophthalmology

摘　　要：目的初步探索抗髓鞘少突胶质细胞糖蛋白抗体（MOG-Ab）在不同临床类型免疫介导性视神经炎（IM-ON）患者血清中的表达。方法采用临床病例横断面研究。2010年5月至2011年2月至北京同仁医院神经内科就诊的免疫介导性视神经炎患者（IM—ON）129例，根据其临床特点分为以下5组：多发性硬化相关视神经炎（MS—ON）20例，视神经脊髓炎相关视神经炎（NMO-ON）13例，自身免疫病相关视神经炎（AON）33例，复发性孤立性视神经炎（RION）43例及单发性孤立性视神经炎（SION）20例。用ELISA方法对其血清中MOG—Ab进行检测，应用SPSS17．0软件，采用χ2检验及方差分析、t检验方法对数据进行统计学分析，比较其阳性率与抗体滴度在不同组间的区别。结果所有129例IM—ON患者中12例（9．3％）患者的血清MOG—Ab阳性。其中MS—ON组血清MOG-Ab阳性者5例（5／20），NMO—ON组0例（0／13），AON组4例（4／33），RION组2例（2／43），SION组1例（1／20）。5组间阳性率差异无统计学意义（Fisher确切概率法，χ2=7．051，P=0．088）。将除MS-ON组之外的其余4组合并为“视神经脊髓炎（NMO）谱系视神经炎”后与MS—ON组比较发现，MS—ON组的MOG—Ab阳性率和抗体滴度均明显高于“NMO谱系视神经炎”组。结论MOG抗体见于除NMO—ON之外的各种类型的IM-ON，在MS—ON患者血清中的表达明显高于“NMO谱系视神经炎”。Objective To investigate the expression of anti-myelin oligodendrocyte glycoprotein antibody （MOG-Ab） in different types of immune-mediated optic neuritis （IM-ON）. Methods Case- control and cross section study. The serum of 129 consecutive cases of immune-mediated optic neuritis （ IM- ON group） seen in Neuro-ophthalmology clinic in Department of Neurology, Beijing Tongren Hospital during May 2010 and February 2011 were collected. All IM-ON cases were further classified into five different types as： 20 cases of multiple sclerosis related ON （MS-ON）, 13 cases of neuromyelitis optica related ON （NMO- ON）, 33 cases of autoimmune optic neuritis （AON）, 43 cases of relapsing isolated optic neuritis （RION） and 20 cases of solitary isolated optic neuritis （SION）. MOG-Ab was tested by ELISA. The positivity rate and titer of MOG-Ab among these groups were compared using chi-square test and ANOVA, t test by SPSS17.0 software. Results MOG-Ab was positive in 12 of all 129 tested IM-ON patients （9. 3% ）, in which there were5 of 20 MS-ON, none of 13 NMO-ON, 4 of 33 AON, 2 of 43 RION, and 1 of 20 SION patients. There were no statistical significant difference among five groups （ Fisher＇s exact test, χ2 =7. 051, P =0. 088 ）, but MS-ON group showed statistically higher MOG-Ab positivity and titer than the ＂ NMO spectrum optic neuritis＂ group which was merged from the other 4 IM-ON groups. Conclusion MOG-Ab could be detected in different types of immune-mediated optic neuritis except NMO-ON and the expression of MOG-Ab was statistically higher in MS-ON group than the ＇NMO spectrum optic neuritis＇ group.

关 键 词：视神经炎 髓磷脂蛋白质类 自身抗体 视神经脊髓炎 多发性硬化 自身免疫疾病 

分 类 号：R774.6[医药卫生—眼科]