宫颈癌Aquilion ONE 320 CT灌注成像表现初探  

A study of CT perfusion imaging of cervical cancer on Aquilion ONE 320

作　　者：钱昊初[1] 郭文力[1] 王思亮[1] 胡天玉[1] 吴荣[1] 

机构地区：[1]中国医科大学附属盛京医院,辽宁沈阳110004

出　　处：《中国临床医学影像杂志》2012年第12期853-855,共3页Journal of China Clinic Medical Imaging

基　　金：辽宁省教育厅课题(2009A723)CT灌注成像在宫颈癌适形调强放射治疗中的应用研究

摘　　要：目的：探讨宫颈癌320CT灌注成像参数及其临床应用价值。方法：对36例临床诊断为宫颈癌患者行子宫颈CT灌注扫描，其中Ⅰ～Ⅱ期宫颈癌组16例，Ⅲ．Ⅳ期宫颈癌组20例，取15例宫颈癌旁正常组织作为对照组。应用PerfusionCT软件包对灌注图像进行后处理，得到时间一密度曲线（Timedensitycurve，TDC），灌注参数包括：血流量（Bloodflow，BF）、血容量（Bloodvolume，BV）及表面通透性（Permeabilitysurface，PS）。结果：Ⅰ一Ⅱ期宫颈癌组和Ⅲ～Ⅳ期宫颈癌组的BF、BV、PS均高于宫旁正常对照组；Ⅲ～Ⅳ期宫颈癌组的BF、BV、PS均高于Ⅰ～Ⅱ期宫颈癌组，差异均有统计学意义（P〈O．05）。灌注值随肿瘤病理分期的升高而增加。结论：子宫颈癌320CT灌注成像作为一种新的影像学方法，反映子宫肿瘤灌注成像参数及其内部灌注状态可靠，对肿瘤的分期及预后评估、评价肿瘤治疗疗效有重要的临床指导意义。Objective： To investigate the parameters obtained with 320 CT perfusion imaging in cervical cancer and the clinical application. Methods： Thirty-six cases of cervical cancer patients were scanned with Aquilion ONE 320 CT, including 16 cases of stage I ~ Ⅱ cervical cancer and 20 cases of stage Ⅳ-Ⅳ cervical cancer. Fifteen cases of parametrial normal tissues were considered as a control group. Time-density curves （TDC）, as well as perfusion parameters, including blood flow （BF）, blood volume（BV） and permeability surface（PS） were post-processed by perfusion CT software package. Results： BF, BV and PS were higher in the stage I ～ Ⅱ and Ⅲ-Ⅳ cervical cancer groups than those in the parametrial normal control group; BF, BV and PS were higher in the stage Ⅲ-Ⅳ group than those in the I ～ Ⅱ stage cervical cancer group, with statistically significant differences （P〈O.05）. Perfusion parameters enhanced with the increase of the tumor stage. Conclusions： 320 CT per- fusion imaging in cervical cancer provides a new method to reliably demonstrate the parameters of perfusion imaging and in- ternal perfusion, thus, it is clinically significant for tumor staging, prognosis and evaluation of tumor therapy.

关 键 词：宫颈肿瘤 体层摄影术 螺旋计算机 

分 类 号：R737.33[医药卫生—肿瘤] R814.42[医药卫生—临床医学]