Stroop色词测验和P300检测在无症状性脑梗死患者认知功能中的应用研究  

Application of Stroop Color-word Association Test and P300 Test in Recognition Function of the Patients with Asymptomatic Cerebral Infarction

作　　者：喻锦成[1] 陈涛[1] 吴小丽[1] 欧阳锋[1] 李朝健[1] 林鹏[1] 符俏[1] 文国强[1] 

机构地区：[1]海南省人民医院,海南省海口市570311

出　　处：《中国全科医学》2012年第35期4058-4060,共3页Chinese General Practice

基　　金：海南省卫生厅课题(琼卫-2008-35)

摘　　要：目的分析无症状性脑梗死(ACI)患者Stroop色词测验(CWT)和P300检测的结果,探讨CWT和P300检测对ACI患者认知功能的评估价值。方法选取2008年1月—2009年1月海南省人民医院神经内科门诊或住院的60例ACI患者,采用蒙特利尔认知评估量表中文版进行认知功能评分,评分≥26分者为对照组29例,评分<26分者为认知障碍组31例,分析比较两组患者CWT及P300检测结果。结果 (1)CWT结果:认知障碍组A卡片、B卡片应用时间及正确阅读数与对照组比较,差异均无统计学意义(P>0.05);认知障碍组C卡片应用时间及正确阅读数与对照组比较,差异均有统计学意义(P<0.05)。(2)P300检测结果:认知障碍组与对照组P300潜伏期及波幅比较,差异均有统计学意义〔(392.7±33.2)ms和(320.8±29.2)ms,(4.2±2.1)μV和(10.3±3.4)μV,t值分别为6.9和7.2,P<0.05〕。结论对ACI患者常规开展CWT和P300检测,可早期发现患者认知功能受损,及时采取治疗措施,可延缓症状加重,改善患者生活质量。Objective To investigate the characteristics of Stroop Color -word Association Test （CWT） and event re- lated potential P300 in patients with asymptomatie cerebral infarction （ACI） and to explore the assessment value of the CWT and P300 test for the recognition function of ACI patients. Methods 60 ACI out - patients and in - patients admitted to neurology department of People＇s Hospital of Hainan Province were divided into control group （29 cases） and cognitive impairment （CI） group （31 cases） according to the scores of Montreal cognitive assessment （MoCA）, with score ≥26 as control group and score 〈 26 as CI group. The results of CWT and P300 test were analyzed and compared between the two groups. Results （ 1 ） CWT results ： The application time and accurate reading in A and B part of CWT between CI group and control group showed no statisti- cally significant differences （ P 〉 0. 05 ） , but the application time and accurate reading in C part of CWT between the two groups showed statistically significant difference （ P 〈 0. 05 ）. （ 2 ） P300 test results ： The latency of P300 and amplitude between the two groups showed statistically significant difference [ （392. 7 ± 33.2） ms vs. （ 320. 8± 29.2） ms, （4. 2 ± 2. 1 ） μV vs. （ 10. 3 ± 3.4） μV, t = 6. 9, 7. 2, P 〈 0. 05 ]. Conclusion Combined CWT and 17300 test is conducive to early detection of cognitive impairment of the patients with ACI, so that early treatment can be performed to delay aggravation of symptoms and im- prove life quality.

关 键 词：无症状性脑梗死 Stroop色词测验 事件相关电位 P300 认知障碍 

分 类 号：R743.33[医药卫生—神经病学与精神病学]