灵芝酸对人体糖代谢调节作用的研究  

The Mechanism of Ganoderic Acid Regulates Human Glucose

作　　者：金德宽[1] 

机构地区：[1]江苏食品职业技术学院食品与营养工程学院,江苏淮安223003

出　　处：《食品研究与开发》2012年第11期202-207,共6页Food Research and Development

基　　金：淮安市科技支撑计划项目(HAG20100044)

摘　　要：研究了灵芝酸对试验小鼠肝脏糖耗量的影响,结果表明灵芝发酵液、菌丝体以及从发酵液中提取的灵芝酸均能提高糖耗量。分析了糖代谢酶活性和中间代谢产物的变化,己糖激酶活性显著增加,乳酸脱氢酶和乳酸含量均有不同程度降低,丙酮酸含量增加,丙酮酸羧化酶和苹果酸脱氢酶活性显著增强,细胞色素氧化酶活性显著增强,灵芝酸主要通过增加糖的好氧代谢提高糖耗量,为灵芝酸广泛的药理活性提供了新的理论参考。The affect of ganoderic acid on murine liver glucose consumption was studied, the results showed that zymotic fluid and mycelium and ganoderic acid from zymotic fluid all increased glucose consumption. Activities of metabolic enzymes and mesostate were analysed. Hexokinase activity was increased significantly. The content of lactate dehydrogenase and lactic acid was depressed in varying degrees. And pyruvic acid content was increased. Enzymes activities of pyruvate carboxylase and malic dehydrogenase was increased remarkably. Cytochrome oxidase activity was significantly enhanced. The ganoderic acids increased glucose consumption by increasing aerobic metabolism of glucose. It provided a new theory foundation for broad pharmacological activities of ganoderma acid.

关 键 词：灵芝酸 发酵液 糖耗量 糖代谢 

分 类 号：R285[医药卫生—中药学]