酰化反应合成N-(2-溴-4-甲氧基苯基)丙烯酰胺的研究  

Synthesis of N-(2-Bromo-4-methoxyphenyl)acrylamide by Acylation

作　　者：袁加程[1] 

机构地区：[1]江苏食品职业技术学院生物与化学工程学院,江苏淮安223003

出　　处：《化学世界》2012年第12期737-739,共3页Chemical World

基　　金：淮安市科技支撑计划项目(HAG09010)

摘　　要：研究了2-溴-4-甲氧基苯胺与丙烯酰氯发生酰化反应合成了N-(2-溴-4-甲氧基苯基)丙烯酰胺的方法。以95.7%的收率得到N-(2-溴-4-甲氧基苯基)丙烯酰胺。探讨了反应物物质的量比、反应时间、反应温度和碱的添加对酰化反应的影响。该方法原料易得,反应条件易于控制,收率高,对环境友好。A method for synthesis of N-（2-bromo-4-methoxyphenyl）acrylamide by acylation was introduced.N-（2-Bromo-4-methoxyphenyl）acrylamide was obtained by the acylation of 2-bromo-4-methoxyaniline with acryloyl chloride in 95.7% yield.The effect of molar ratio of reactants,reaction temperature,reaction time and the addition of alkali on the acylation reaction was studied.The new procedure for preparing N-（2-bromo-4-methoxyphenyl）acrylamide has the advantages of easy source of material,good yield,simple operation and environmental benignity.

关 键 词：N-(2-溴-4-甲氧基苯基)丙烯酰胺 2-溴-4-甲氧基苯胺 酰化 

分 类 号：TQ224.7[化学工程—有机化工] O621.3[理学—有机化学]