复方苦参注射液联合GP方案治疗晚期非小细胞肺癌临床疗效及生存质量影响  

Influence of Compound Matrine Injection Combined with GP Regimen on Therapeutic Efficacy and the Quality of Life in Patients with Advanced Non-small Cell Lung Cancer

作　　者：赵凯[1] 杨俊泉[1] 王建华[1] 李义慧[1] 王洪娟[1] 张爱静[1] 

机构地区：[1]河北省唐山市人民医院放化疗科,河北唐山063001

出　　处：《实用预防医学》2012年第12期1853-1854,共2页Practical Preventive Medicine

摘　　要：目的观察复方苦参注射液联合GP方案治疗晚期非小细胞肺癌的疗效及对患者生存质量的影响,为临床工作提供参考。方法选择唐山市人民医院2009年8月-2011年7月收治的晚期非小细胞肺癌患者86例,随机分为对照组和观察组各43例。全部患者均给予GP方案治疗,观察组患者在此基础上给予复方苦参素注射液治疗,连续治疗2个疗程,观察并比较两组患者临床疗效和生存质量的差异。结果与对照组比较,观察组总有效率、临床受益率未见提高,差异无统计学意义(P>0.05),生活质量评分(KPS)明显提高,差异有统计学意义(P<0.01)。结论采用复方苦参注射液联合GP方案治疗晚期非小细胞肺癌,改善患者生存质量,值得推广应用。Objective To observe the therapeutic efficacy of compound matrine injection combined with GP regimen and the effect of the combination regimen on the quality of life in patients with advanced non-small cell lung cancer（NSCLC）,and to provide reference for clinical practice.Methods Eighty-six patients with advanced NSCLC hospitalized in the People＇s Hospital of Tangshan City from August 2009 to July 2011 were randomly divided into control group and observation group（each n=43）.The patients in control group were treated with the GP regimen,while the patients in observation group were given the combination regimen.After 2 courses of continuous treatment（14 days for a course）,the clinical curative effect and the quality of life were observed and compared between the two groups.Results No statistically significant difference was found in the total effective rate and the clinical beneficial rate between the two groups（P0.05）.The Karnofsky performance scale（KPS） scores in observation group were significantly increased,and the difference was statistically significant between the two groups（P0.01）.Conclusions The compound matrine injection in combination with GP regimen is effective in improving the quality of life of patients with advanced NSCLC.It is worth popularizing and applying.

关 键 词：复方苦参注射液 GP方案 晚期非小细胞肺癌 临床疗效 生存质量 

分 类 号：R734.2[医药卫生—肿瘤]